Description

2-(4-Hydroxyphenyl)acetohydrazide (CAS No. 20277-02-5) is a high-purity organic compound with the molecular formula C₈H₁₀N₂O₂, widely used in pharmaceutical and biochemical research. This white to off-white crystalline powder exhibits a molecular weight of 166.18 g/mol and is characterized by its hydrazide functional group attached to a 4-hydroxyphenylacetic acid moiety. Its structural features make it a valuable intermediate in the synthesis of heterocyclic compounds, Schiff bases, and other bioactive molecules. The product is rigorously tested for purity (typically ≥95% by HPLC) and is supplied in sealed containers under inert conditions to ensure stability. Ideal for medicinal chemistry, this compound is soluble in polar organic solvents such as DMSO, methanol, and ethanol, but has limited solubility in water. Store at 2-8°C in a dry environment to prolong shelf life.

Properties

• CAS Number: 20277-02-5
• Complexity: 153
• IUPAC Name: 2-(4-hydroxyphenyl)acetohydrazide
• InChI: InChI=1S/C8H10N2O2/c9-10-8(12)5-6-1-3-7(11)4-2-6/h1-4,11H,5,9H2,(H,10,12)
• InChI Key: YJKVPKGOZNHONU-UHFFFAOYSA-N
• Exact Mass: 166.074227566
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• SMILES: C1=CC(=CC=C1CC(=O)NN)O
• Topological: 75.4
• Monoisotopic Mass: 166.074227566
• Synonyms: 2-(4-hydroxyphenyl)acetohydrazide, 20277-02-5, DTXSID30395658, DTXCID60346517, (4-Hydroxy-phenyl)-acetic acid hydrazide, Benzeneacetic acid, 4-hydroxy-, hydrazide, MFCD01922174, (4-Hydroxyphenyl)acetic acid hydrazide, 4-(???methyl)phenol, Oprea1_296885, oxyphenylacetic acid hydrazide, SCHEMBL2492150, YJKVPKGOZNHONU-UHFFFAOYSA-N, ALBB-002667, BBL016572, STK424594, AKOS000305698, AS-12070, (4-hydroxy -phenyl)-acetic acid hydrazide, DB-013909, CS-0116771, ST50926908, H22251, EN300-7361961

Application

2-(4-Hydroxyphenyl)acetohydrazide serves as a key precursor in the synthesis of antimicrobial, anticancer, and anti-inflammatory agents due to its reactive hydrazide group. Researchers utilize it to develop Schiff base ligands for metal coordination complexes in catalytic and material science applications. It is also employed in the preparation of hydrazone derivatives for studying enzyme inhibition and receptor binding interactions.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.