Description

2-(4-Fluorophenyl)cyclopropanecarboxylic acid (CAS No. 879324-64-8) is a high-purity fluorinated cyclopropane derivative with the molecular formula C₁₀H₉FO₂. This compound features a cyclopropane ring substituted with a carboxylic acid group and a 4-fluorophenyl moiety, making it a valuable building block for pharmaceutical and agrochemical research. Its rigid cyclopropane structure and fluorine substitution enhance metabolic stability and bioavailability, ideal for drug discovery applications. Available in >98% purity (HPLC), this product is supplied as a white to off-white crystalline powder, rigorously tested via NMR, LC-MS, and elemental analysis to ensure consistency. Suitable for use in organic synthesis, medicinal chemistry, and as a precursor for bioactive molecules. Store in a cool, dry place under inert conditions to maintain stability.

Properties

• CAS Number: 879324-64-8
• Complexity: 209
• IUPAC Name: 2-(4-fluorophenyl)cyclopropanecarboxylic acid
• InChI: InChI=1S/C10H9FO2/c11-7-3-1-6(2-4-7)8-5-9(8)10(12)13/h1-4,8-9H,5H2,(H,12,13)
• InChI Key: QJJWMUZHTDQZDW-UHFFFAOYSA-N
• Exact Mass: 180.05865769
• Molecular Formula: C10H9FO2
• Molecular Weight: 180.17
• SMILES: C1C(C1C(=O)O)C2=CC=C(C=C2)F
• Topological: 37.3
• Monoisotopic Mass: 180.05865769
• Synonyms: 2-(4-fluorophenyl)cyclopropanecarboxylic acid, 879324-64-8, 2-(4-fluorophenyl)cyclopropane-1-carboxylic acid, MFCD06804481, 2-(4-FLUORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID, 2-(4-Fluorophenyl)cyclopropanecarboxylicAcid, (1R,2R)-2-(4-Fluorophenyl)cyclopropanecarboxylicAcid, trans-2-(4-Fluoro-phenyl)-cyclopropanecarboxylic acid, (1R,2R)-2-(4-Fluorophenyl)cyclopropanecarboxylic Acid, Cyclopropanecarboxylic acid, 2-(4-fluorophenyl)-, cis-2-(4-fluorophenyl)cyclopropane-1-carboxylic acid, SCHEMBL1019425, DTXSID90619024, QJJWMUZHTDQZDW-UHFFFAOYSA-N, EKB32464, MFCD30717787, MFCD31555875, SBB084049, AKOS000365553, AKOS016042102, CCG-357875, CS-W000605, DS-4288, SB18424, SB34284, SB39316, AC-29362, SY020770, SY266079, SY266080, DB-346138, EN300-25356, Z203244232

Application

2-(4-Fluorophenyl)cyclopropanecarboxylic acid is widely utilized as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of CNS-active compounds and enzyme inhibitors. Its cyclopropane scaffold is employed to modulate conformational rigidity in drug candidates, while the fluorine atom enhances binding affinity. Researchers also leverage this compound in agrochemical studies to design novel pesticides with improved metabolic resistance. Additionally, it serves as a precursor for chiral ligands in asymmetric catalysis.

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