Description

2-(4-(Chloromethyl)phenyl)-1-methyl-4-(trifluoromethyl)-1H-imidazole (CAS: 2446481-81-6) is a high-purity, synthetic organic compound with the molecular formula C₁₂H₁₀ClF₃N₂. This specialized chemical features a chloromethylphenyl group and a trifluoromethyl-substituted imidazole core, making it a valuable intermediate for pharmaceutical and agrochemical research. Its unique structure offers reactivity for further functionalization, particularly in the development of bioactive molecules. The compound is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring consistency for sensitive applications. Proper storage at 2-8°C in a tightly sealed container under inert atmosphere is recommended to maintain stability. This product is intended for research purposes only and is not for human or veterinary use.

Properties

• CAS Number: 2446481-81-6
• Complexity: 277
• IUPAC Name: 2-[4-(chloromethyl)phenyl]-1-methyl-4-(trifluoromethyl)imidazole
• InChI: InChI=1S/C12H10ClF3N2/c1-18-7-10(12(14,15)16)17-11(18)9-4-2-8(6-13)3-5-9/h2-5,7H,6H2,1H3
• InChI Key: YPFNXASBVZHBHX-UHFFFAOYSA-N
• Exact Mass: 274.0484605
• Molecular Formula: C12H10ClF3N2
• Molecular Weight: 274.67
• SMILES: CN1C=C(N=C1C2=CC=C(C=C2)CCl)C(F)(F)F
• Topological: 17.8
• Monoisotopic Mass: 274.0484605
• Synonyms: 2-(4-(Chloromethyl)phenyl)-1-methyl-4-(trifluoromethyl)-1H-imidazole, 2446481-81-6, SCHEMBL22122019, YPFNXASBVZHBHX-UHFFFAOYSA-N, G88818, 2-[4-(Chloromethyl)phenyl]-1-methyl-4-(trifluoromethyl)imidazole

Application

This compound serves as a key building block in medicinal chemistry, particularly for developing potential kinase inhibitors and antimicrobial agents. Researchers utilize its reactive chloromethyl group for further derivatization in drug discovery programs. The trifluoromethyl moiety enhances metabolic stability, making it valuable for pharmacokinetic optimization studies. It has shown promise in early-stage development of treatments for inflammatory diseases.

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