Description

2-(4-(Chloromethyl)phenyl)-1-isopropyl-4-(trifluoromethyl)-1H-imidazole (CAS No. 2857089-64-4) is a high-purity, synthetic organic compound with the molecular formula C₁₄H₁₄ClF₃N₂. This specialized imidazole derivative features a chloromethylphenyl group and a trifluoromethyl substitution, making it a valuable intermediate in pharmaceutical and agrochemical research. Its IUPAC name is 2-[4-(chloromethyl)phenyl]-1-propan-2-yl-4-(trifluoromethyl)imidazole, and it is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC). Suitable for use in medicinal chemistry, this compound is rigorously tested for identity, purity, and stability, ensuring reliable performance in nucleophilic substitution reactions, cross-coupling reactions, and as a building block for bioactive molecules. Packaged under inert gas to prevent degradation, it is ideal for researchers requiring precise structural modifications in drug discovery.

Properties

• CAS Number: 2857089-64-4
• Complexity: 314
• IUPAC Name: 2-[4-(chloromethyl)phenyl]-1-isopropyl-4-(trifluoromethyl)imidazole
• InChI: InChI=1S/C14H14ClF3N2/c1-9(2)20-8-12(14(16,17)18)19-13(20)11-5-3-10(7-15)4-6-11/h3-6,8-9H,7H2,1-2H3
• InChI Key: CFONUJWRRYOELW-UHFFFAOYSA-N
• Exact Mass: 302.0797606
• Molecular Formula: C14H14ClF3N2
• Molecular Weight: 302.72
• SMILES: CC(C)N1C=C(N=C1C2=CC=C(C=C2)CCl)C(F)(F)F
• Topological: 17.8
• Monoisotopic Mass: 302.0797606
• Synonyms: 2-(4-(Chloromethyl)phenyl)-1-isopropyl-4-(trifluoromethyl)-1H-imidazole, 2857089-64-4, 2-[4-(Chloromethyl)phenyl]-1-isopropyl-4-(trifluoromethyl)-1H-imidazole, SCHEMBL25729750, SY312316

Application

This compound serves as a key intermediate in the synthesis of trifluoromethyl-substituted imidazole derivatives, which are pivotal in developing pharmaceuticals and agrochemicals. Its reactive chloromethyl group enables facile functionalization for targeted molecule design, particularly in kinase inhibitor research. The trifluoromethyl moiety enhances metabolic stability, making it valuable for optimizing drug candidates.

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