Description

2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (CAS: 722-92-9) is a high-purity fluorinated organic compound with the molecular formula C₉H₇F₆NO. This specialty chemical features a unique hexafluoropropanol group attached to a para-aminophenyl moiety, making it highly valuable for advanced research and industrial applications. Its trifluoromethyl groups enhance lipophilicity and metabolic stability, while the amino group provides reactivity for further functionalization. Ideal for use in pharmaceutical intermediates, agrochemical synthesis, and materials science, this compound is supplied as a crystalline solid with guaranteed purity (>96%) and stringent quality control. Store in a cool, dry place under inert conditions to ensure stability.

Properties

• CAS Number: 722-92-9
• Complexity: 252
• IUPAC Name: 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol
• InChI: InChI=1S/C9H7F6NO/c10-8(11,12)7(17,9(13,14)15)5-1-3-6(16)4-2-5/h1-4,17H,16H2
• InChI Key: TZEJXCIGVMTMDY-UHFFFAOYSA-N
• Exact Mass: 259.04318282
• Molecular Formula: C9H7F6NO
• Molecular Weight: 259.15
• SMILES: C1=CC(=CC=C1C(C(F)(F)F)(C(F)(F)F)O)N
• Topological: 46.3
• Monoisotopic Mass: 259.04318282
• Synonyms: 722-92-9, 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, DTXSID50992926, DTXCID401419989, 670-530-0, 4-(Hexafluoro-2-hydroxyisopropyl)aniline, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol, MFCD00039258, 2-(4-Aminophenyl)hexafluoro-2-propanol, 2-(4-AMINOPHENYL)HEXAFLUOROPROPAN-2-OL, MLS000564290, 4-Amino-alpha,alpha-bis(trifluoromethyl)benzyl Alcohol, Enamine_005408, Benzenemethanol,4-amino-a,a-bis(trifluoromethyl)-, SCHEMBL289673, CHEMBL1499171, SGLSVIUONDXTPO-UHFFFAOYSA-N, 2-(4-Amino-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol, HMS1409F18, HMS2395B16, ALBB-010196, BBL003950, SBB018382, STK522204, AKOS001053137, CS-W004983, GS-6686, SMR000151804, ST065359, SY046978, 4-(hexafluoro-2-hydroxy-2-propyl)aniline, 4-(hexafluoro-2-hydroxy-2-propyl)-aniline, DB-055623, EN300-02317, 4-Amino-a,a-bis(trifluoromethyl)benzenemethanol, p-Amino-a,a-bis(trifluoromethyl)benzyl alcohol, 4-Amino-A,alpha-Bis(Trifluoromethyl)-Benzenemethanol, Z56922114, 2-(4-Amino-phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol #, 4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)aniline, benzenemethanol, 4-amino-alpha,alpha-bis(trifluoromethyl)-, 1-(4-aminophenyl)-1-trifluoromethyl-2,2,2-trifluoroethanol, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol, 96%, 2-Hydroxy-2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropane, 4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-aniline, 4-(1-Hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)aniline, Benzenemethanol, 4-amino-.alpha.,.alpha.-bis(trifluoromethyl)-, 4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)-ethyl]benzenamine, 4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenylamine, 2-(4-Aminophenyl)-1 pound not1 pound not1 pound not3 pound not3 pound not3-hexafluoropropan-2-ol

This compound serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of kinase inhibitors and CNS-active agents. Its electron-withdrawing trifluoromethyl groups make it useful for modifying drug solubility and bioavailability. Researchers also employ it in materials science for creating high-performance polymers with enhanced thermal and chemical resistance. Additionally, it finds applications in agrochemical research for designing novel pesticides and herbicides.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (16.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (16.7%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.