Description

2-(3,5-Difluorophenyl)-2-fluoroacetic acid (CAS No. 208259-38-5) is a high-purity fluorinated organic compound with the molecular formula C₈H₅F₃O₂. This specialty chemical features a difluorophenyl ring coupled with a fluoroacetic acid moiety, making it a valuable intermediate for pharmaceutical, agrochemical, and materials science research. Its unique structure enables precise modifications in drug design and functional material synthesis. Available in quantities from milligrams to kilograms, our product undergoes rigorous QC testing (HPLC, NMR) to ensure ≥98% purity, meeting the stringent demands of research and industrial applications. Store in a cool, dry place under inert conditions to maintain stability.

Properties

• CAS Number: 208259-38-5
• Complexity: 188
• IUPAC Name: 2-(3,5-difluorophenyl)-2-fluoro-acetic acid
• InChI: InChI=1S/C8H5F3O2/c9-5-1-4(2-6(10)3-5)7(11)8(12)13/h1-3,7H,(H,12,13)
• InChI Key: MZVNGSGHYLFNHX-UHFFFAOYSA-N
• Exact Mass: 190.02416388
• Molecular Formula: C8H5F3O2
• Molecular Weight: 190.12
• SMILES: C1=C(C=C(C=C1F)F)C(C(=O)O)F
• Topological: 37.3
• Monoisotopic Mass: 190.02416388
• Synonyms: 2-(3,5-difluorophenyl)-2-fluoroacetic acid, 208259-38-5, 965-591-8, SCHEMBL4416888, MZVNGSGHYLFNHX-UHFFFAOYSA-N, (3,5-difluorophenyl)fluoroacetic acid, AKOS017531318, (3, 5-difluorophenyl)fluoroacetic acid, 3,5-difluorophenyl-alpha-fluoroacetic acid, alpha-Fluoro-3,5-difluorophenylacetic Acid, 2-(3,5-difluorophenyl)-2-fluoroaceticacid, CS-0344179, EN300-1138492

Application

2-(3,5-Difluorophenyl)-2-fluoroacetic acid serves as a key building block in medicinal chemistry for the synthesis of fluorinated drug candidates, particularly in CNS and anti-inflammatory therapies. Its difluorophenyl group enhances metabolic stability in bioactive molecules, while the fluoroacetic acid moiety facilitates conjugation. Researchers also utilize this compound to develop advanced materials with tailored electronic properties. It is particularly useful in PET radiotracer development due to fluorine-18 labeling potential.

Safety and Hazards

GHS Hazard Statements

• H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.