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Atomfair 2-(3′,5′-Difluoro-[1,1′-biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane F77754 C18H19BF2O2

Description 2-(3′,5′-Difluoro-[1,1′-biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS No. 2250042-17-0) is a high-purity boronic ester derivative with the molecular formula C18H19BF2O2. This compound features a biphenyl core functionalized with difluorophenyl and dioxaborolane groups, making it a versatile building block for Suzuki-Miyaura cross-coupling reactions in organic synthesis. Its rigid aromatic structure and boronate ester moiety enhance stability and reactivity, ideal for constructing complex pharmaceutical intermediates or advanced materials. Supplied as a crystalline solid with ??95% purity (HPLC), it is rigorously tested for moisture-sensitive applications. Store under inert conditions (argon/nitrogen) at 2-8??C to maintain integrity.

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Description

Description

2-(3′,5′-Difluoro-[1,1′-biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS No. 2250042-17-0) is a high-purity boronic ester derivative with the molecular formula C18H19BF2O2. This compound features a biphenyl core functionalized with difluorophenyl and dioxaborolane groups, making it a versatile building block for Suzuki-Miyaura cross-coupling reactions in organic synthesis. Its rigid aromatic structure and boronate ester moiety enhance stability and reactivity, ideal for constructing complex pharmaceutical intermediates or advanced materials. Supplied as a crystalline solid with ??95% purity (HPLC), it is rigorously tested for moisture-sensitive applications. Store under inert conditions (argon/nitrogen) at 2-8??C to maintain integrity.

  • CAS No: 2250042-17-0
  • Molecular Formula: C18H19BF2O2
  • Molecular Weight: 316.2
  • Exact Mass: 316.1446163
  • Monoisotopic Mass: 316.1446163
  • IUPAC Name: 2-[4-(3,5-difluorophenyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC=C(C=C2)C3=CC(=CC(=C3)F)F
  • Synonyms: 2-(3′,5′-Difluoro-[1,1′-biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 2250042-17-0, F77754

Application

This compound is widely used as a key intermediate in the synthesis of bioactive molecules, particularly in pharmaceutical research for fluorinated drug candidates. Its boronate ester group enables efficient cross-coupling reactions to form biaryl structures common in kinase inhibitors. The difluorophenyl moiety enhances metabolic stability in medicinal chemistry applications. Researchers also employ it in materials science for creating fluorinated organic semiconductors.

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