Description

2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethanamine (CAS No. 658066-44-5) is a high-purity, specialized organic compound with the molecular formula C₈H₈ClF₃N₂. This pyridine derivative features a chloro-substituted trifluoromethylpyridine core with an ethanamine side chain, making it a valuable intermediate for pharmaceutical and agrochemical synthesis. Its unique structure enables versatile reactivity in cross-coupling reactions, nucleophilic substitutions, and other functional group transformations. Supplied as a crystalline solid or solution, this compound is rigorously tested for purity (typically ≥95% by HPLC or GC analysis) and stability under recommended storage conditions (2-8°C under inert atmosphere). Ideal for medicinal chemistry research, this building block is particularly useful in developing bioactive molecules targeting CNS disorders and pest control agents.

Properties

• CAS Number: 658066-44-5
• Complexity: 186
• IUPAC Name: 2-[3-chloro-5-(trifluoromethyl)-2-pyridyl]ethanamine
• InChI: InChI=1S/C8H8ClF3N2/c9-6-3-5(8(10,11)12)4-14-7(6)1-2-13/h3-4H,1-2,13H2
• InChI Key: BEESBQNARXNIDL-UHFFFAOYSA-N
• Exact Mass: 224.0328104
• Molecular Formula: C8H8ClF3N2
• Molecular Weight: 224.61
• SMILES: C1=C(C=NC(=C1Cl)CCN)C(F)(F)F
• Topological: 38.9
• Monoisotopic Mass: 224.0328104
• Synonyms: 658066-44-5, 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethanamine, 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine, 2-[3-Chloro-5-(trifluoromethyl)-2-pyridyl]ethanamine, MFCD11848345, 2-(3-Chloro-5-(trifluoromethyl)-pyridin-2-yl)ethanamine, 2-(2-Aminoethyl)-3-chloro-5-(trifluoromethyl)pyridine, 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethan-1-amine, 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethan-1-amine, 2-(3-CHLORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-ETHYLAMINE, 2-Pyridineethanamine, 3-chloro-5-(trifluoromethyl)-, SCHEMBL1122017, DTXSID00474843, AKOS016012941, AB64799, AS-69621, DB-329225, CS-0201438, EN300-132680, 2-(3-chloro-5-trifluormethyl-pyridin-2-yl)-ethylamine, 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-ethylamine

Application

This compound serves as a key intermediate in the synthesis of novel pharmaceuticals, particularly for neuroactive compounds targeting neurotransmitter systems. Its structural features make it valuable for developing crop protection agents with improved efficacy against resistant pest strains. Researchers utilize this building block in Suzuki-Miyaura couplings and other palladium-catalyzed reactions to create diverse heterocyclic scaffolds for drug discovery programs.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P333+P317, P337+P317, P362+P364, P391, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Sens. 1 (100%)
• Eye Irrit. 2 (100%)
• Aquatic Chronic 2 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.