Description

2-(2,2,2-Trifluoroethoxy)ethan-1-ol (CAS No. 2358-54-5) is a high-purity fluorinated organic compound with the molecular formula C₄H₇F₃O₂. This versatile chemical is widely used in pharmaceutical synthesis, agrochemical development, and specialty material applications due to its unique trifluoroethoxy functional group. The product is supplied as a clear, colorless liquid with exceptional stability and compatibility with a wide range of organic solvents. Our material meets rigorous quality control standards, ensuring batch-to-batch consistency for research and industrial applications. Suitable for use as a building block in medicinal chemistry, this compound offers excellent potential for creating novel fluorinated derivatives with enhanced biological activity.

Properties

• CAS Number: 2358-54-5
• Complexity: 70.7
• IUPAC Name: 2-(2,2,2-trifluoroethoxy)ethanol
• InChI: InChI=1S/C4H7F3O2/c5-4(6,7)3-9-2-1-8/h8H,1-3H2
• InChI Key: HRBLSBRWIWIOGW-UHFFFAOYSA-N
• Exact Mass: 144.03981395
• Molecular Formula: C4H7F3O2
• Molecular Weight: 144.09
• SMILES: C(COCC(F)(F)F)O
• Topological: 29.5
• Monoisotopic Mass: 144.03981395
• Synonyms: 2-(2,2,2-trifluoroethoxy)ethan-1-ol, 630-402-7, 2-(2,2,2-trifluoroethoxy)ethanol, 2358-54-5, Ethanol, 2-(2,2,2-trifluoroethoxy)-, 2-(2,2,2-Trifluoro-ethoxy)-ethanol, MFCD00462508, 5,5,5-Trifluoro-3-oxapentan-1-ol, 5-Hydroxy-1,1,1-trifluoro-3-oxapentane, NSC81800, Ethanol,2-(2,2,2-trifluoroethoxy)-, 2-hydroxyethyl 2,2,2-trifluoroethyl ether, NCIOpen2_000956, SCHEMBL39141, SCHEMBL39142, Ethanol,2,2-trifluoroethoxy)-, LCZC2701, SCHEMBL21487960, SCHEMBL28103138, DTXSID90292336, HRBLSBRWIWIOGW-UHFFFAOYSA-N, 2-(2,2,2-trifluoroethoxyl)ethanol, 2-(2,2,2-trifluoro-ethoxy)ethanol, NSC-81800, SBB056421, AKOS005363287, AS-62278, SY060566, 2-hydroxyethyl 2,2,2-trifluorethyl ether, CS-0059814, EN300-73737, F20478, Z820715426

This fluorinated alcohol derivative serves as a valuable intermediate in pharmaceutical research, particularly for developing novel drug candidates with improved metabolic stability. The trifluoroethoxy group enhances lipophilicity, making it useful for medicinal chemistry applications targeting CNS-active compounds. In material science, it functions as a precursor for specialty polymers with unique surface properties. The compound also finds application in agrochemical research for developing next-generation crop protection agents.

Safety and Hazards

GHS Hazard Statements

• H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (25%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (25%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (25%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (25%)
• Acute Tox. 4 (25%)
• Skin Corr. 1B (25%)
• Skin Irrit. 2 (50%)
• Eye Irrit. 2 (50%)
• Acute Tox. 4 (25%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.