Description

2-(2-Fluoro-5-nitrophenyl)acetic acid (CAS No. 195609-18-8) is a high-purity fluorinated nitroaromatic compound with the molecular formula C₈H₆FNO₄. This fine chemical is characterized by its acetic acid functional group attached to a 2-fluoro-5-nitrophenyl ring, making it a valuable intermediate in organic synthesis and pharmaceutical research. With a molecular weight of 199.14 g/mol, this compound is supplied as a crystalline solid with >95% purity (HPLC). Its unique structure enables versatile reactivity, including nucleophilic aromatic substitution and reduction of the nitro group. Proper storage at 2-8°C in a tightly sealed container is recommended to maintain stability. This product is intended for research purposes only and is not for human or veterinary use.

Properties

• CAS Number: 195609-18-8
• Complexity: 240
• IUPAC Name: 2-(2-fluoro-5-nitro-phenyl)acetic acid
• InChI: InChI=1S/C8H6FNO4/c9-7-2-1-6(10(13)14)3-5(7)4-8(11)12/h1-3H,4H2,(H,11,12)
• InChI Key: IDWINSICBKJFBK-UHFFFAOYSA-N
• Exact Mass: 199.02808583
• Molecular Formula: C8H6FNO4
• Molecular Weight: 199.14
• SMILES: C1=CC(=C(C=C1[N+](=O)[O-])CC(=O)O)F
• Topological: 83.1
• Monoisotopic Mass: 199.02808583
• Synonyms: 2-(2-fluoro-5-nitrophenyl)acetic acid, 816-003-2, 2-Fluoro-5-nitrophenylacetic acid, 195609-18-8, (2-fluoro-5-nitrophenyl)acetic acid, MFCD04091773, 2-FLUORO-5-NITROBENZENEACETIC ACID, {2-fluoro-5-nitrophenyl}acetic acid, Benzeneacetic acid, 2-fluoro-5-nitro-, 2-Fluoro-5-nitrophenylaceticAcid, (2-Fluoro-5-nitro-phenyl)-acetic acid, AO-635/14620007, SCHEMBL1578785, SCHEMBL15819946, DTXSID40357282, IDWINSICBKJFBK-UHFFFAOYSA-N, 2-fluoro-5-nitrophenyl acetic acid, 2-Fluoro-5-nitro-benzeneacetic acid, BBL102484, SBB063667, STL556287, AKOS006229418, CS-W003147, GS-4425, 2-(2-fluoro-5-nitrophenyl) acetic acid, SY005249, DB-017517, EN300-344991

Application

2-(2-Fluoro-5-nitrophenyl)acetic acid serves as a key building block in medicinal chemistry for the development of novel pharmaceutical compounds. Researchers utilize this compound in the synthesis of fluorinated drug candidates, particularly those targeting inflammatory pathways. The nitro group provides an excellent handle for further functionalization through reduction to amines or conversion to other nitrogen-containing functionalities. In material science, it finds application as a precursor for specialty polymers with unique electronic properties.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.