Description

2-(2-Chloroethoxy)acetamide (CAS No. 36961-64-5) is a high-purity organic compound with the molecular formula C₄H₈ClNO₂. This white to off-white crystalline solid is a versatile intermediate in organic synthesis and pharmaceutical research. With a molecular weight of 137.57 g/mol, it features a chloroethoxy side chain linked to an acetamide group, offering unique reactivity for nucleophilic substitutions and condensation reactions. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied in sealed containers under inert atmosphere to guarantee stability. Ideal for researchers developing novel drug candidates, agrochemicals, or specialty polymers. Available in gram to kilogram quantities with optional certificates of analysis.

Properties

• CAS Number: 36961-64-5
• Complexity: 76.4
• IUPAC Name: 2-(2-chloroethoxy)acetamide
• InChI: InChI=1S/C4H8ClNO2/c5-1-2-8-3-4(6)7/h1-3H2,(H2,6,7)
• InChI Key: KQHRCXCLILUNBX-UHFFFAOYSA-N
• Exact Mass: 137.0243562
• Molecular Formula: C4H8ClNO2
• Molecular Weight: 137.56
• SMILES: C(CCl)OCC(=O)N
• Topological: 52.3
• Monoisotopic Mass: 137.0243562
• Synonyms: 2-(2-chloroethoxy)acetamide, 36961-64-5, DTXSID30452013, DTXCID90402832, 609-321-6, MFCD00800223, Acetamide, 2-(2-chloroethoxy)-, 2-chloroethoxyacetamide, 2-chloroethoxy acetamide, (2-chloroethoxy)acetamide, 2-(2-chlorethoxy)acetamide, 2-(2-chloroethoxy)-acetamide, SCHEMBL1405264, KQHRCXCLILUNBX-UHFFFAOYSA-N, BCP29906, AKOS005068098, AS-19229, SY007262, DB-003889, CS-0149936, F15040, EN300-1707120, 2-chloroethoxyacetamide pound>>N-(2-Chloroethoxy)-acetamide

Application

2-(2-Chloroethoxy)acetamide serves as a key building block in pharmaceutical synthesis, particularly for β-blocker analogs and antineoplastic agents. The chloroethoxy moiety enables facile ether formation in nucleophilic substitution reactions. Researchers utilize this compound as a precursor for heterocyclic systems in medicinal chemistry programs. Its dual functional groups allow for selective modifications in multi-step synthetic routes.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (33.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (33.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H341 (33.3%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

Precautionary Statements

• P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (33.3%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (33.3%)
• Muta. 2 (33.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.