Description

2-(2-(2-Fluorophenyl)-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)acetic acid (CAS No. 1080644-24-1) is a high-purity, synthetic heterocyclic compound with the molecular formula C₁₇H₁₃FN₄O₅. This pyrido[2,3-d]pyrimidine derivative features a fluorophenyl substituent and a carboxamidoacetic acid moiety, making it a valuable intermediate for pharmaceutical research and medicinal chemistry applications. The compound is supplied as a fine powder with ≥95% purity (HPLC), ensuring consistency for advanced biochemical studies. Its unique structure offers potential as a scaffold for kinase inhibitors or other targeted therapeutics. Store at -20°C under inert conditions for optimal stability.

Properties

• CAS Number: 1080644-24-1
• Complexity: 670
• IUPAC Name: 2-[[2-(2-fluorophenyl)-5-hydroxy-8-methyl-7-oxo-pyrido[2,3-d]pyrimidine-6-carbonyl]amino]acetic acid
• InChI: InChI=1S/C17H13FN4O5/c1-22-15-9(6-19-14(21-15)8-4-2-3-5-10(8)18)13(25)12(17(22)27)16(26)20-7-11(23)24/h2-6,25H,7H2,1H3,(H,20,26)(H,23,24)
• InChI Key: AWDNMFGPRPQSTI-UHFFFAOYSA-N
• Exact Mass: 372.08699769
• Molecular Formula: C17H13FN4O5
• Molecular Weight: 372.31
• SMILES: CN1C2=NC(=NC=C2C(=C(C1=O)C(=O)NCC(=O)O)O)C3=CC=CC=C3F
• Topological: 133
• Monoisotopic Mass: 372.08699769
• Synonyms: 1080644-24-1, 2-(2-(2-Fluorophenyl)-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)acetic acid, 2-[[2-(2-fluorophenyl)-5-hydroxy-8-methyl-7-oxopyrido[2,3-d]pyrimidine-6-carbonyl]amino]acetic acid, CHEMBL3115302, 2-(2-(2-Fluorophenyl)-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-6-carboxamido)acetic acid, SCHEMBL336916, DTXSID70716449, BDBM50446897, AKOS016004896, 2-(2-(2-Fluorophenyl)-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)aceticacid, N-[[2-(2-FLUOROPHENYL)-7,8-DIHYDRO-5-HYDROXY-8-METHYL-7-OXOPYRIDO[2,3-D]PYRIMIDIN-6-YL]CARBONYL]GLYCINE, DB-059682, N-[2-(2-Fluorophenyl)-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonyl]glycine

Application

This fluorinated pyridopyrimidine derivative is primarily utilized in medicinal chemistry research as a key intermediate for the development of kinase inhibitors and other small-molecule therapeutics. Its structural features make it suitable for structure-activity relationship (SAR) studies in oncology and inflammatory disease research. The compound’s reactive sites allow for further derivatization to explore novel pharmacophores. Researchers may employ it in high-throughput screening assays or as a building block for targeted drug discovery programs.

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