Description

(1S)-3-(Dimethylamino)-1-(thiophen-2-yl)propan-1-ol (CAS No. 132335-44-5) is a chiral organic compound with the molecular formula C₉H₁₅NOS. This high-purity chemical features a thiophene ring and a dimethylamino functional group, making it a valuable intermediate in pharmaceutical and agrochemical research. Its well-defined stereochemistry (S-configuration) ensures precise reactivity in asymmetric synthesis. The compound is supplied as a stable solid or liquid (depending on storage conditions) and is rigorously tested for purity via HPLC, GC, or NMR to meet research-grade standards. Suitable for use in medicinal chemistry, catalysis, and material science applications. Store under inert conditions at recommended temperatures to maintain stability.

Properties

• CAS Number: 132335-44-5
• Complexity: 130
• IUPAC Name: (1S)-3-(dimethylamino)-1-(2-thienyl)propan-1-ol
• InChI: InChI=1S/C9H15NOS/c1-10(2)6-5-8(11)9-4-3-7-12-9/h3-4,7-8,11H,5-6H2,1-2H3/t8-/m0/s1
• InChI Key: XWCNSHMHUZCRLN-QMMMGPOBSA-N
• Exact Mass: 185.08743528
• Molecular Formula: C9H15NOS
• Molecular Weight: 185.29
• SMILES: CN(C)CC[C@@H](C1=CC=CS1)O
• Topological: 51.7
• Monoisotopic Mass: 185.08743528
• Synonyms: 132335-44-5, (1S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol, DTXSID10433380, EC 603-565-7, DTXCID70384208, (S)-N,N-DIMETHYL-3-(2-THIENYL)-3-HYDROXYPROPANAMINE, 603-565-7, (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine, S-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl)Propanamine, (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol, (S)-n,n-dimethyl-3-hydroxy-3-(2-thienyl)propanamine, (1S)-3-(dimethylamino)-1-thiophen-2-ylpropan-1-ol, 2-THIOPHENEMETHANOL, ALPHA-[2-(DIMETHYLAMINO)ETHYL]-, (ALPHAS)-, (S)-1-BETA-HYDROXY-1-(2-THIENYL)-3-DIMETHYLAMINOPROPANE, C9H15NOS, MFCD07782107, (S)-(-)-N,N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)PROPYLAMINE, (S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol, (1S)-3-(DIMETHYLAMINO)-1-(2-THIENYL)PROPAN-1-OL, SCHEMBL522925, CHEMBL4551881, Duloxetine IMpurity 17;(S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol, XWCNSHMHUZCRLN-QMMMGPOBSA-N, AC-367, AKOS006285188, AKOS015850814, CS-W023104, DS-1075, ID58105, D4010, EN300-91510, (S)-3-dimethylamino-1-(2-thienyl)-1-propanol, (s)-3-(dimethylamino)-1-(thienyl)-propan-1-ol, 3-Hydroxy-N,N-dimethyl-3-(2-thienyl)propanamine, (S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol, (S)-2-[3-(Dimethylamino)-1-hydroxypropyl]thiophene, (S)-1-?-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane, (S)-1-b-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane, (S)-3-(dimethylamino)-1-(thiophen-2-yl) propan-1-ol, (S)-(-)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropanamine, (s)-n,n-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine, (S)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propylamine, (S)-1- beta -Hydroxy-1-(2-thienyl)-3-dimethylaminopropane, 2-Thiophenemethanol, |A-[2-(dimethylamino)ethyl]-, (|AS)-, S-(+)-N,N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)-1-PROPYLAMIDE, (S)-1-b-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane;S-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Application

(1S)-3-(Dimethylamino)-1-(thiophen-2-yl)propan-1-ol is a key chiral building block in the synthesis of bioactive molecules, particularly for central nervous system (CNS) drug discovery. It serves as a precursor for ligands and catalysts in asymmetric reactions due to its stereocenter. Researchers also utilize it in the development of thiophene-based polymers for electronic materials. Its structural motifs are relevant in agrochemical design for pest control agents.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (16.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (16.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Skin Irrit. 2 (66.7%)
• Eye Dam. 1 (16.7%)
• Eye Irrit. 2A (66.7%)
• Acute Tox. 4 (16.7%)
• STOT SE 3 (50%)

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