Description

(1R,2S)-2,3-Dihydro-2,6-dimethyl-1H-inden-1-amine (CAS No. 752984-24-0) is a high-purity chiral amine compound with the molecular formula C₁₁H₁₅N. This optically active indane derivative is synthesized for advanced research applications, particularly in asymmetric synthesis and pharmaceutical development. The compound features a rigid indane backbone with stereogenic centers at the 1- and 2-positions, making it valuable for studying stereoselective reactions. Available as a white to off-white crystalline solid with ≥95% purity (HPLC), it is supplied in sealed containers under inert gas to ensure stability. Researchers utilize this building block for designing novel bioactive molecules, receptor ligands, and catalysts. Store at 2-8°C in a dry environment.

Properties

• CAS Number: 752984-24-0
• Complexity: 166
• IUPAC Name: (1R,2S)-2,6-dimethylindan-1-amine
• InChI: InChI=1S/C11H15N/c1-7-3-4-9-6-8(2)11(12)10(9)5-7/h3-5,8,11H,6,12H2,1-2H3/t8-,11+/m0/s1
• InChI Key: NMRCYNVWDPJOAC-GZMMTYOYSA-N
• Exact Mass: 161.120449483
• Molecular Formula: C11H15N
• Molecular Weight: 161.24
• SMILES: C[C@H]1CC2=C([C@@H]1N)C=C(C=C2)C
• Topological: 26
• Monoisotopic Mass: 161.120449483
• Synonyms: (1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-amine, (1R,2S)-2,3-Dihydro-2,6-dimethyl-1H-inden-1-amine, 700-140-9, 1351564-23-2, 752984-24-0, (1R,2S)-2,6-Dimethylindan-1-amine, SCHEMBL1734307, SCHEMBL1735412, NMRCYNVWDPJOAC-GZMMTYOYSA-N, DTXSID201019351, NS00007394, EN300-261617, (1R,2S)-2,6-dimethyl-2,3-dihydro-1H-indene-1-amine

Application

This chiral amine serves as a key intermediate in the synthesis of pharmacologically active compounds, particularly for central nervous system targets. Researchers employ it in asymmetric catalysis studies due to its rigid bicyclic structure and defined stereochemistry. The compound has shown utility in developing novel dopamine receptor modulators and serotonergic agents. Its constrained geometry makes it valuable for conformational studies in medicinal chemistry programs.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P260, P264, P264+P265, P270, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Corr. 1B (100%)
• Eye Dam. 1 (100%)
• Aquatic Chronic 3 (100%)

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