Description

(1R,2R)-trans-N-Boc-2-Aminocyclopentanol (CAS: 454170-16-2) is a high-purity chiral compound with the molecular formula C₁₀H₁₉NO₃. This Boc-protected aminocyclopentanol derivative is widely used in pharmaceutical research and organic synthesis as a versatile building block for the preparation of complex molecules. The compound is characterized by its stereospecific (1R,2R)-trans configuration, ensuring high enantiomeric purity (≥98.5% by GC). It is supplied as a white to off-white crystalline powder with excellent stability under standard storage conditions. This product is ideal for medicinal chemistry applications, including the synthesis of bioactive compounds and chiral auxiliaries.

Key Features:

• High enantiomeric purity (≥98.5% by GC)
• Boc-protected amine for selective deprotection
• Stable under inert atmosphere and refrigeration
• Suitable for peptide coupling and asymmetric synthesis
• Strict quality control with analytical data (HPLC, GC, NMR)

Properties

• CAS Number: 454170-16-2
• Complexity: 210
• IUPAC Name: tert-butyl N-[(1R,2R)-2-hydroxycyclopentyl]carbamate
• InChI: InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-7-5-4-6-8(7)12/h7-8,12H,4-6H2,1-3H3,(H,11,13)/t7-,8-/m1/s1
• InChI Key: CGZQRJSADXRRKN-HTQZYQBOSA-N
• Exact Mass: 201.13649347
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.26
• SMILES: CC(C)(C)OC(=O)N[C@@H]1CCC[C@H]1O
• Topological: 58.6
• Monoisotopic Mass: 201.13649347
• Synonyms: (1R,2R)-trans-N-Boc-2-aminocyclopentanol, 155837-14-2, rac-tert-butyl N-[(1R,2R)-2-hydroxycyclopentyl]carbamate, rac-tert-butyl N-((1R,2R)-2-hydroxycyclopentyl)carbamate, 624-456-0, 852-607-2, 454170-16-2, tert-Butyl ((1R,2R)-2-hydroxycyclopentyl)carbamate, tert-butyl N-[(1R,2R)-2-hydroxycyclopentyl]carbamate, (1-(4-Methylphenylimino)ethyl)ferrocene, tert-Butyl (trans-2-hydroxycyclopentyl)carbamate, tert-butyl (1R,2R)-2-hydroxycyclopentylcarbamate, 155890-37-2, MFCD11656037, tert-Butyl [(1R,2R)-2-hydroxycyclopentyl]carbamate, tert-butyl (1R,2R)-2-hydroxycyclopentyl, trans-tert-butyl 2-hydroxycyclopentylcarbamate, tert-Butyl N-(trans-2-hydroxycyclopentyl)carbamate, Carbamic acid, [(1R,2R)-2-hydroxycyclopentyl]-, 1,1-dimethylethyl ester, rel-tert-Butyl ((1R,2R)-2-hydroxycyclopentyl)carbamate, SCHEMBL764578, DTXSID20666925, CGZQRJSADXRRKN-HTQZYQBOSA-N, SBB062684, AKOS015909336, DS-3951, DB-298987, CS-0166815, EN300-60737, tert-butyl trans-2-hydroxycyclopentylcarbamate, EN300-249905, N10593, tert-Butyl(trans-2-hydroxycyclopentyl)carbamate, trans-2-(tert-butoxycarbonyl)aminocyclopentan-1-ol, trans-tert-Butyl N-[-2-hydroxycyclopentyl]carbamate, trans-N-(tert-butyloxycarbonyl)-2-hydroxycyclopentylamine, Z954610106, N-((1R,2R)-2-hydroxycyclopentyl)(tert-butoxy)carboxamide, racemic trans-tert-butyl N-[2-hydroxycyclopentyl]carbamate, trans- N-(tert-butyloxycarbonyl)-2-hydroxycyclopentylamine, (1R,2R)-trans-N-Boc-2-aminocyclopentanol, >=98.5% (GC), Carbamic acid,[(1R,2R)-2-hydroxycyclopentyl]-,1,1-dimethylethyl ester,rel-

(1R,2R)-trans-N-Boc-2-Aminocyclopentanol is used as a chiral intermediate in the synthesis of pharmaceutical compounds, particularly in asymmetric catalysis and peptidomimetics. It serves as a key precursor for bioactive molecules targeting neurological and metabolic disorders. The Boc protection allows selective functionalization of the amine group while maintaining the hydroxyl group for further derivatization.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.