Description

1,4-Piperazinediethanesulfonic acid, potassium salt (1:2) (CAS No. 108321-27-3) is a high-purity biochemical buffer agent widely utilized in molecular biology, biochemistry, and pharmaceutical research. This dipotassium salt derivative of PIPES (Piperazine-1,4-bis(2-ethanesulfonic acid)) offers enhanced solubility and buffering capacity in the physiological pH range (6.1-7.5). With the molecular formula C₈H₁₆K₂N₂O₆S₂, it provides exceptional stability for enzyme assays, cell culture media, and electrophoresis applications. Our product is rigorously tested for low endotoxin levels, heavy metal content, and batch-to-batch consistency, meeting the stringent requirements of in vitro diagnostic and bioprocessing workflows. Available in crystalline form with ≥99% purity (HPLC), it is ideal for sensitive applications requiring minimal UV absorbance.

Properties

• CAS Number: 108321-27-3
• Complexity: 370
• IUPAC Name: dipotassium;2-[4-(2-sulfonatoethyl)piperazin-1-yl]ethanesulfonate
• InChI: InChI=1S/C8H18N2O6S2.2K/c11-17(12,13)7-5-9-1-2-10(4-3-9)6-8-18(14,15)16;;/h1-8H2,(H,11,12,13)(H,14,15,16);;/q;2*+1/p-2
• InChI Key: BJQYFCAMUXGZFN-UHFFFAOYSA-L
• Exact Mass: 377.9723916
• Molecular Formula: C8H16K2N2O6S2
• Molecular Weight: 378.6
• SMILES: C1CN(CCN1CCS(=O)(=O)[O-])CCS(=O)(=O)[O-].[K+].[K+]
• Topological: 138
• Monoisotopic Mass: 377.9723916
• Physical Description: White solid;
• Synonyms: 108321-27-3, 1,4-Piperazinediethanesulfonic acid, dipotassium salt, DTXSID9073042, 1,4-Piperazinediethanesulfonic acid, potassium salt (1:2), DTXCID1033111, PIPES dipotassium salt, Potassium 2,2′-(piperazine-1,4-diyl)diethanesulfonate, Piperazine-N,N’-bis-(2-ethanesulphonic acid) dipotassium salt, dipotassium 2-[4-(2-sulfonatoethyl)piperazin-1-yl]ethanesulfonate, MFCD00069751, dipotassium;2-[4-(2-sulfonatoethyl)piperazin-1-yl]ethanesulfonate, Piperazine-1,4-bis(2-ethanesulfonic acid ) dipotassium salt, Piperazine-1,4-bis(2-ethanesulfonic acid) dipotassium salt, Piperazine-N,N/’-bis-(2-ethanesulphonic acid) dipotassium salt, dipotassium 2-[4-(2-sulfonatoethyl)piperazin-1-yl]ethane-1-sulfonate, 1,4-Piperazinediethanesulfonic acid dipotassium salt, BJQYFCAMUXGZFN-UHFFFAOYSA-L, SCHEMBL9897196, Piperazine-N,N’-bis-(2-ethanesulphonic acid)dipotassium salt, dipotassium,2-[4-(2-sulfonatoethyl)piperazin-1-yl]ethanesulfonate, AKOS015903810, AKOS024464834, MB00529, AS-82237, DS-017714, CS-0368276, dipotassium 1,4-piperazine-diethanesulfonate, PIPES dipotassium salt, >=99% (titration), H11291, PIPES dipotassium salt, Vetec(TM) reagent grade, 99%, Piperazine-1,4-bis(2-ethanesulfonic acid)dipotassium salt, Potassium 2,2′-(piperazine-1,4-diyl)bis(ethane-1-sulfonate)

Application

This dipotassium PIPES salt serves as an effective buffering agent for cell culture systems, particularly where phosphate interference must be avoided. It is commonly employed in bacterial growth media, protein crystallization studies, and as a component of electrophoresis running buffers. The compound’s zwitterionic properties make it suitable for maintaining pH stability in redox-sensitive biochemical assays. Researchers also utilize it in chromatography mobile phases to improve peak resolution of biomolecules.

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