Description

Description

1,4-Difluoro-2-isocyanatobenzene (CAS No. 39718-32-6) is a high-purity aromatic isocyanate compound with the molecular formula C₇H₃F₂NO. This specialized chemical features a benzene ring substituted with two fluorine atoms at the 1- and 4-positions and a reactive isocyanate group (-N=C=O) at the 2-position. With a molecular weight of 155.10 g/mol, this compound is particularly valuable in advanced organic synthesis and pharmaceutical research due to its dual functionality as both an electrophile (isocyanate) and a fluorinated aromatic building block. The product is supplied as a clear to pale yellow liquid (exact physical state depends on storage conditions) and should be handled under inert atmosphere due to moisture sensitivity. Typical purity ??95% (GC), with exact specifications available on request. Suitable for use in Suzuki couplings, urea formations, and other nucleophilic addition reactions.

Application

1,4-Difluoro-2-isocyanatobenzene serves as a key intermediate in pharmaceutical development, particularly for creating fluorinated urea derivatives through reactions with amines. The compound’s isocyanate group enables efficient conjugation with biomolecules for proteomics research, while its fluorinated aromatic structure contributes to enhanced metabolic stability in drug candidates. Researchers utilize this chemical in materials science to synthesize fluorinated polyurethanes with unique surface properties.

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