Description

1,4-Dibromo-2,5-difluorobenzene (CAS No. 327-51-5) is a high-purity halogenated aromatic compound with the molecular formula C₆H₂Br₂F₂. This crystalline solid is widely utilized in organic synthesis, pharmaceutical intermediates, and advanced material research due to its unique reactivity and structural properties. Its IUPAC name, 1,4-dibromo-2,5-difluorobenzene, reflects the precise substitution pattern of bromine and fluorine atoms on the benzene ring, making it a valuable building block for cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitutions. Available in ≥98% purity (GC), it is packaged under inert conditions to ensure stability. Suitable for R&D and industrial applications, this compound is handled with strict adherence to safety protocols (GHS hazard codes apply).

Properties

• CAS Number: 327-51-5
• Complexity: 106
• IUPAC Name: 1,4-dibromo-2,5-difluoro-benzene
• InChI: InChI=1S/C6H2Br2F2/c7-3-1-5(9)4(8)2-6(3)10/h1-2H
• InChI Key: GLVMLJCMUBZVTJ-UHFFFAOYSA-N
• Exact Mass: 271.84708
• Molecular Formula: C6H2Br2F2
• Molecular Weight: 271.88
• SMILES: C1=C(C(=CC(=C1Br)F)Br)F
• Monoisotopic Mass: 269.84913
• Synonyms: 1,4-Dibromo-2,5-difluorobenzene, 327-51-5, Benzene, 1,4-dibromo-2,5-difluoro-, VAY7VM7HFU, 2,5-dibromo-1,4-difluorobenzene, EINECS 206-317-2, DTXSID70186365, 2,5-difluoro-1,4-dibromobenzene, DTXCID80108856, 206-317-2, 1,4-dibromo-2,5-difluoro-benzene, MFCD00000346, Maybridge1_003946, UNII-VAY7VM7HFU, SCHEMBL505780, SCHEMBL4015022, HMS552L08, CCG-45049, AKOS000121616, CS-W005505, FD11144, 1,4-Dibromo-2,5-difluorobenzene, 98%, AC-23639, BP-21231, SY014461, D1864, NS00041534, EN300-21224, SR-01000634842-1, InChI=1/C6H2Br2F2/c7-3-1-5(9)4(8)2-6(3)10/h1-2

Application

1,4-Dibromo-2,5-difluorobenzene serves as a key intermediate in the synthesis of liquid crystals, agrochemicals, and pharmaceuticals. Its electron-deficient aromatic ring facilitates palladium-catalyzed coupling reactions to construct complex biaryl systems. Researchers also employ it in the development of fluorinated polymers and OLED materials due to its thermal stability and halogen-directed reactivity. Precursor for functionalized aromatics in materials science.

Safety and Hazards

GHS Hazard Statements

• H315 (98%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (96%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (98%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (96%)

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