Description

1,4-Bis(trifluoromethyl)benzene (CAS No. 433-19-2) is a high-purity fluorinated aromatic compound with the molecular formula C₈H₄F₆. This specialty chemical features two trifluoromethyl groups symmetrically positioned on a benzene ring, offering exceptional thermal stability, chemical resistance, and low polarizability. Its unique structure makes it valuable for advanced applications in pharmaceuticals, agrochemicals, and materials science. Available in research quantities with ≥98% purity (GC), this compound is rigorously tested for consistency and quality. Suitable for use as a building block in organic synthesis, ligand design, and fluorinated polymer development. Packaged under inert gas to ensure stability and shipped with detailed analytical certificates (GC/MS, NMR).

Properties

• CAS Number: 433-19-2
• Complexity: 161
• IUPAC Name: 1,4-bis(trifluoromethyl)benzene
• InChI: InChI=1S/C8H4F6/c9-7(10,11)5-1-2-6(4-3-5)8(12,13)14/h1-4H
• InChI Key: PDCBZHHORLHNCZ-UHFFFAOYSA-N
• Exact Mass: 214.02171910
• Molecular Formula: C8H4F6
• Molecular Weight: 214.11
• SMILES: C1=CC(=CC=C1C(F)(F)F)C(F)(F)F
• Monoisotopic Mass: 214.02171910
• Physical Description: Colorless liquid;
• Vapor Pressure: 18.5 [mmHg]
• Synonyms: 1,4-Bis(trifluoromethyl)benzene, 433-19-2, 1,4-di(Trifluoromethyl)benzene, Benzene, 1,4-bis(trifluoromethyl)-, p-trifluoromethylbenzotrifluoride, A7C3RX7Y2R, alpha,alpha,alpha,alpha’,alpha’,alpha’-Hexafluoro-p-xylene, NSC-61992, DTXSID1059991, 1,4-Bis-trifluoromethyl-benzene, .alpha.,.alpha.,.alpha.,.alpha.’,.alpha.’,.alpha.’-Hexafluoro-p-xylene, Hexafluoropxylene, pBis(trifluoromethyl)benzene, DTXCID5040257, Benzene, 1,4bis(trifluoromethyl), alpha,alpha,alpha,alpha’,alpha’,alpha’Hexafluoropxylene, pXylene, alpha,alpha,alpha,alpha’,alpha’,alpha’hexafluoro, pXylene, alpha,alpha,alpha,alpha’,alpha’,alpha’hexafluoro(8CI), 207-086-0, inchi=1/c8h4f6/c9-7(10,11)5-1-2-6(4-3-5)8(12,13)14/h1-4, pdcbzhhorlhncz-uhfffaoysa-n, un1993, Hexafluoro-p-xylene, p-Bis(trifluoromethyl)benzene, 1,4-bis-trifluoromethylbenzene, MFCD00000402, NSC 61992, p-Xylene, alpha,alpha,alpha,alpha’,alpha’,alpha’-hexafluoro-, p-Xylene, .alpha.,.alpha.,.alpha.,.alpha.’,.alpha.’,.alpha.’-hexafluoro-, 1,4-Di(trifluoromethyl)benzene; NSC 61992PTF-TFM; p-Bis(trifluoromethyl)benzene; p-Trifluoromethylbenzotrifluoride; p-Xylene hexafluoride; alpha,alpha,alpha,alpha’,alpha’,alpha’-Hexafluoro-p-xylene, NSC61992, EINECS 207-086-0, p-xylene hexafluoride, UNII-A7C3RX7Y2R, SCHEMBL63468, SCHEMBL221733, SCHEMBL8778382, Benzene,4-bis(trifluoromethyl)-, A,A,A,A’,A’-hexafluoro-p-xylene, FD2076, SBB094913, AKOS000120050, 1,4-Bis(trifluoromethyl)benzene, 98%, AC-13881, PS-11445, DB-024019, B1408, NS00043352, ST50307029, EN300-20090, A826241, Z104476788, .alpha.,.alpha.,.alpha.’,.alpha.’,.alpha.’-Hexafluoro-p-xylene, p-Xylene,.alpha.,.alpha.,.alpha.’,.alpha.’,.alpha.’-hexafluoro-, 433-01-2

Application

1,4-Bis(trifluoromethyl)benzene serves as a key intermediate in the synthesis of liquid crystals and OLED materials due to its electron-withdrawing properties. It is utilized in pharmaceutical research to create metabolically stable analogs of bioactive compounds. The compound also functions as a precursor for fluorinated polymers with enhanced chemical and thermal resistance.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.