Description

1,4-Bis(chloromethyl)-2,3,5,6-tetrafluorobenzene (CAS No. 131803-37-7) is a highly specialized fluorinated aromatic compound with the molecular formula C₈H₄Cl₂F₄. This organofluorine building block features two reactive chloromethyl groups and a tetrafluorinated benzene core, making it an invaluable intermediate for advanced synthetic applications. The compound’s unique electronic properties, imparted by the electron-withdrawing fluorine substituents, enhance its utility in nucleophilic substitution reactions and cross-coupling methodologies. Supplied as a high-purity solid (>95%), it is rigorously tested by GC-MS and ¹H/¹⁹F NMR to ensure batch-to-batch consistency. Ideal for pharmaceutical, agrochemical, and materials science research, this product is packaged under inert atmosphere in amber glass vials to maintain stability. Handle with appropriate PPE due to lachrymatory potential of chloromethyl groups.

Properties

• CAS Number: 131803-37-7
• Complexity: 156
• IUPAC Name: 1,4-bis(chloromethyl)-2,3,5,6-tetrafluoro-benzene
• InChI: InChI=1S/C8H4Cl2F4/c9-1-3-5(11)7(13)4(2-10)8(14)6(3)12/h1-2H2
• InChI Key: WEUAASLFNKTIIM-UHFFFAOYSA-N
• Exact Mass: 245.9626182
• Molecular Formula: C8H4Cl2F4
• Molecular Weight: 247.01
• SMILES: C(C1=C(C(=C(C(=C1F)F)CCl)F)F)Cl
• Monoisotopic Mass: 245.9626182
• Synonyms: 131803-37-7, 1,4-bis(chloromethyl)-2,3,5,6-tetrafluorobenzene, DTXSID70373495, DTXCID10324527, 1,4-Bis(chloromethyl)tetrafluorobenzene, Benzene, 1,4-bis(chloromethyl)-2,3,5,6-tetrafluoro-, MFCD03424467, SCHEMBL2522605, AKOS005254335, DB-042061

Application

This tetrafluorobenzene derivative serves as a key precursor for synthesizing fluorinated liquid crystals and dielectric materials in display technologies. Its bifunctional reactivity enables polymerization into high-performance polyarylether resins with exceptional thermal and chemical resistance. Researchers also employ it to construct fluorinated MOFs (Metal-Organic Frameworks) for gas storage applications, leveraging the enhanced polarizability of the fluorinated aromatic system.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (100%)

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