Description

1,4-Bis(2,2,2-trifluoroethoxy)benzene (CAS No. 66300-61-6) is a high-purity fluorinated aromatic compound with the molecular formula C₁₀H₈F₆O₂. This specialty chemical features a benzene ring symmetrically substituted with two 2,2,2-trifluoroethoxy groups at the 1 and 4 positions, imparting unique electronic and steric properties. The compound’s trifluoroethoxy substituents enhance its lipophilicity and chemical stability, making it valuable for advanced material synthesis and pharmaceutical applications. Available in >98% purity by HPLC, this product is rigorously tested for consistency and meets stringent quality control standards. Suitable for research and industrial use, it is supplied in amber glass bottles under inert atmosphere to ensure long-term stability.

Key identifiers:

• IUPAC Name: 1,4-bis(2,2,2-trifluoroethoxy)benzene
• Synonyms: EINECS 266-304-2, DTXSID90216517
• Molecular Weight: 274.16 g/mol
• Appearance: White to off-white crystalline solid
• Storage: Store at 2-8°C in dry, well-ventilated area

Properties

• CAS Number: 66300-61-6
• Complexity: 216
• IUPAC Name: 1,4-bis(2,2,2-trifluoroethoxy)benzene
• InChI: InChI=1S/C10H8F6O2/c11-9(12,13)5-17-7-1-2-8(4-3-7)18-6-10(14,15)16/h1-4H,5-6H2
• InChI Key: ZHUBFESHPMGIDZ-UHFFFAOYSA-N
• Exact Mass: 274.04284847
• Molecular Formula: C10H8F6O2
• Molecular Weight: 274.16
• SMILES: C1=CC(=CC=C1OCC(F)(F)F)OCC(F)(F)F
• Topological: 18.5
• Monoisotopic Mass: 274.04284847
• Synonyms: 1,4-Bis(2,2,2-trifluoroethoxy)benzene, 66300-61-6, EINECS 266-304-2, DTXSID90216517, DTXCID20139008, 266-304-2, MFCD00042272, C10H8F6O2, SCHEMBL289505, SCHEMBL498377, CCG-4694, CS-M0607, AKOS016001409, 1,4-Di-(2,2,2-trifluoroethoxy)benzene, PS-11082, SY316621, 1,4-bis(2,2,2-trifluoroethoxy) benzene, 1,4-Bis-(2,2,2-trifluoroethoxy)benzene, NS00053760, ST50826807, 2,2,2-trifluoro-1-[4-(2,2,2-trifluoroethoxy)phenoxy]ethane

Application

1,4-Bis(2,2,2-trifluoroethoxy)benzene serves as a versatile building block in medicinal chemistry, particularly for developing fluorinated drug candidates with enhanced metabolic stability. The compound finds application as a specialty monomer for synthesizing high-performance polymers with improved thermal and chemical resistance. Researchers utilize this chemical as a precursor for liquid crystal materials and dielectric fluids in advanced electronic applications. Its unique electronic properties make it valuable for studying charge-transfer complexes in materials science.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.