Description

1,3,5-Trifluorobenzene (CAS No. 372-38-3) is a high-purity fluorinated aromatic compound with the molecular formula C₆H₃F₃. This symmetrically substituted benzene derivative is characterized by its three fluorine atoms at the 1, 3, and 5 positions, offering exceptional chemical stability and unique electronic properties. Ideal for advanced research applications, our 1,3,5-Trifluorobenzene is rigorously tested to meet the highest purity standards (≥98% by GC), ensuring reliable performance in synthetic chemistry, material science, and pharmaceutical development. The compound is supplied in amber glass bottles under inert atmosphere to prevent degradation, with options for custom quantities and analytical documentation (NMR, MS, HPLC) upon request. Key synonyms include sym-Trifluorobenzene and Benzene, 1,3,5-trifluoro-.

Properties

• CAS Number: 372-38-3
• Complexity: 63.3
• IUPAC Name: 1,3,5-trifluorobenzene
• InChI: InChI=1S/C6H3F3/c7-4-1-5(8)3-6(9)2-4/h1-3H
• InChI Key: JXUKFFRPLNTYIV-UHFFFAOYSA-N
• Exact Mass: 132.01868458
• Molecular Formula: C6H3F3
• Molecular Weight: 132.08
• SMILES: C1=C(C=C(C=C1F)F)F
• Monoisotopic Mass: 132.01868458
• Physical Description: Colorless liquid;
• Vapor Pressure: 104.0 [mmHg]
• Synonyms: 1,3,5-TRIFLUOROBENZENE, 372-38-3, sym-Trifluorobenzene, Benzene, 1,3,5-trifluoro-, UNII-BN94C411F8, BN94C411F8, EINECS 206-751-2, NSC-10264, DTXSID90190686, NSC 10264, DTXCID30113177, 206-751-2, jxukffrplntyiv-uhfffaoysa-n, MFCD00000333, 1,3,5-TRIFLUORO BENZENE, 1,5-Trifluorobenzene, 1,3,5-trifluorbenzol, Benzene,3,5-trifluoro-, 1,3,5-tri-fluorobenzene, 1,3,5-Trifluorobenzene #, SCHEMBL57470, SCHEMBL449836, SCHEMBL5167497, SCHEMBL15522653, 1,3,5-Trifluorobenzene, 97%, NSC10264, SBB085805, XH1408, AKOS005258293, FT70543, PS-10252, NS00041741, T1039, EN300-25659, Q27274766

Application

1,3,5-Trifluorobenzene serves as a versatile building block in organic synthesis, particularly in the preparation of fluorinated liquid crystals and specialty polymers. Its electron-withdrawing fluorine substituents make it valuable in pharmaceutical intermediates and agrochemical development. The compound is also employed as a solvent or reagent in nucleophilic aromatic substitution reactions and as a precursor for advanced materials with tailored dielectric properties.

Safety and Hazards

GHS Hazard Statements

• H225 (97.9%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (97.9%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.