Description

1,3,4-Thiadiazol-2-amine, 5-(trifluoromethyl)- (CAS No. 10444-89-0) is a high-purity heterocyclic organic compound with the molecular formula C₃H₂F₃N₃S. This specialized chemical features a thiadiazole core substituted with a trifluoromethyl group and an amine functionality, making it a valuable intermediate for pharmaceutical and agrochemical research. Its unique structure offers excellent reactivity for derivatization and functionalization in synthetic chemistry applications. Available in various quantities, this compound is rigorously tested for quality, ensuring consistency for demanding laboratory and industrial applications. Store in a cool, dry place away from light and moisture to maintain stability.

Properties

• CAS Number: 10444-89-0
• Complexity: 127
• IUPAC Name: 5-(trifluoromethyl)-1,3,4-thiadiazol-2-amine
• InChI: InChI=1S/C3H2F3N3S/c4-3(5,6)1-8-9-2(7)10-1/h(H2,7,9)
• InChI Key: LTEUXHSAYOSFGQ-UHFFFAOYSA-N
• Exact Mass: 168.99215274
• Molecular Formula: C3H2F3N3S
• Molecular Weight: 169.13
• SMILES: C1(=NN=C(S1)N)C(F)(F)F
• Topological: 80
• Monoisotopic Mass: 168.99215274
• Solubility: 17 [ug/mL]
• Synonyms: 10444-89-0, 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole, 5-(Trifluoromethyl)-1,3,4-thiadiazol-2-amine, 2-Amino-5-(trifluoromethyl)-1,3,4-thiadiazole, 1,3,4-Thiadiazol-2-amine, 5-(trifluoromethyl)-, EINECS 233-930-2, NSC 231655, 1,3,4-Thiadiazole, 2-amino-5-(trifluoromethyl)-, DTXSID4065078, DTXCID4032879, 233-930-2, MFCD00003109, 5-Trifluoromethyl-[1,3,4]thiadiazol-2-ylamine, EN300-31423, F3143-0097, 5-(trifluoromethyl)-1,3,4-thiadiazole-2-ylamine, NSC231655, Maybridge1_003448, MLS001004764, SCHEMBL294025, 2-AMINO-5-TRIFLUOROMETHYL-1,3,4-THIADIAZ OLE, SCHEMBL2879537, CHEMBL1311331, HMS551E16, BDBM626137, HMS2666K05, SMSSF-0053667, ALBB-000173, CS-D0490, GEO-00205, SBB020947, STK347897, AKOS000225115, 6K-633S, NSC-231655, SDCCGMLS-0065806.P001, NCGC00246021-01, SMR000348329, SY048743, 2-Amino-5-trifluoromethyl-1,3,4-triazole, DB-020451, ST4011879, 5-trifluoromethyl2-amino-1,3,4-thiadiazole, NS00051923, 2-Amino-5-(trifluoromethyl)-1,4-thiadiazole, 2-amino-5-trifluoromethyl[1,3,4]thiadiazole, 2-trifluoromethyl-5-amino-1,3,4-thiadiazole, 5-trifluoromethyl-2-amino-1,3,4-thiadiazole, VU0301508-3, 1,4-Thiadiazol-2-amine, 5-(trifluoromethyl)-, 2-amino-5-(trifluormethyl)-1,3,4-thiadiazole, 5-trifluoromethyl- 2-amino-1,3,4-thiadiazole, 5-trifluoromethyl-1,3,4-thiadiazole-2-ylamine, F50734, 1,3,4-Thiadiazole, 2-amino-5-trifluoromethyl-, 1,4-Thiadiazole, 2-amino-5-(trifluoromethyl)-, 5-(trifluoromethyl)-1,3,4-thiadiazol-2-ylamine, 5-(trifluoromethyl)-1,3,4-thiadiazole-2-amine, AB00590159-02, 5-(Trifluoromethyl)-1,3,4-thiadiazol-2-amine #, AG-389/00757061, 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole, 97%, Z56791151

Application

1,3,4-Thiadiazol-2-amine, 5-(trifluoromethyl)-, is widely utilized as a key building block in medicinal chemistry for the synthesis of bioactive molecules, including potential antiviral and antibacterial agents. Its trifluoromethyl group enhances lipophilicity and metabolic stability, making it valuable in drug discovery. Researchers also employ this compound in agrochemical development for designing novel pesticides and herbicides. Additionally, it serves as a precursor for advanced materials and coordination chemistry studies.

Safety and Hazards

GHS Hazard Statements

• H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (97.9%)
• Eye Irrit. 2 (97.9%)
• STOT SE 3 (95.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.