Description

1,3,2-Dioxathiane 2,2-Dioxide (CAS No. 1073-05-8) is a high-purity cyclic sulfate compound with the molecular formula C₃H₆O₄S. This versatile reagent is widely utilized in organic synthesis, particularly as a key intermediate for the preparation of complex molecules such as deoxy salacinols. Its cyclic sulfate structure offers excellent reactivity in coupling reactions, enabling efficient functionalization of target compounds. The product is supplied as a white to off-white crystalline solid with ≥98% purity (HPLC), ensuring consistent performance in demanding research applications. Suitable for use under inert conditions, it is packaged in amber glass bottles to maintain stability and prevent degradation. Ideal for pharmaceutical, agrochemical, and materials science research.

Properties

• CAS Number: 1073-05-8
• Complexity: 141
• IUPAC Name: 1,3,2-dioxathiane 2,2-dioxide
• InChI: InChI=1S/C3H6O4S/c4-8(5)6-2-1-3-7-8/h1-3H2
• InChI Key: OQYOVYWFXHQYOP-UHFFFAOYSA-N
• Exact Mass: 137.99867984
• Molecular Formula: C3H6O4S
• Molecular Weight: 138.14
• SMILES: C1COS(=O)(=O)OC1
• Topological: 61
• Monoisotopic Mass: 137.99867984
• Synonyms: 1073-05-8, Trimethylene sulfate, 1,3,2-Dioxathiane, 2,2-dioxide, 1,3-Propylene sulfate, 1,3-Propanediol, cyclic sulfate, NSC 526595, UNII-U6R4I8LVEF, 1,3-Propanediol, cyclic sulphate, U6R4I8LVEF, EINECS 214-022-5, BRN 0774775, 1,3-propylene sulphate, NSC-526595, TRIMETHYLENE SULPHATE, DTXSID4061460, PROPANO-1,3-DIYL SULFATE, PROPYLENE SULFATE, 1,3-, PROPANO-1,3-DIYL SULPHATE, PROPYLENE SULPHATE, 1,3-, 3-01-00-02161 (Beilstein Handbook Reference), 1,3Propylene sulfate, 1,3Propanediol, cyclic sulfate, DTXCID8033065, 214-022-5, oqyovywfxhqyop-uhfffaoysa-n, 1,3,2-Dioxathiane 2,2-dioxide, 1,3,2-dioxathiane-2,2-dione, 1,3-Propanediol cyclic sulfate, 1,3,2-DIOXATHIANE2,2-DIOXIDE, [1,3,2]dioxathiane 2,2-dioxide, 1,3,2lambda-dioxathiane-2,2-dione, MFCD00801144, NSC526595, SCHEMBL51770, 1,3,2lambda6-dioxathiane-2,2-dione, AKOS015907881, 1,3-Propanediol cyclic sulfate, 98%, FD61299, BS-30033, SY052762, CS-0204556, D4427, NS00023453, F20412, EN300-1725068, Q27290765, 1,3-Propanediol Cyclic Sulfate;1,3-Propylene Sulfate;Trimethylene Sulfate

Application

1,3,2-Dioxathiane 2,2-Dioxide is primarily employed as a reagent in the synthesis of deoxy salacinols via coupling reactions. Its cyclic sulfate group acts as a reactive handle for nucleophilic substitution, facilitating the construction of complex glycosidic structures. Researchers also utilize it as a propylene glycol equivalent in polymer chemistry and as a precursor for sulfated organic compounds. Its stability and selectivity make it valuable for controlled functionalization in medicinal chemistry workflows.

Safety and Hazards

GHS Hazard Statements

• H318 (11.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H341 (11.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
• H351 (93%): Suspected of causing cancer [Warning Carcinogenicity]

Precautionary Statements

• P203, P264+P265, P280, P305+P354+P338, P317, P318, P405, and P501

Hazard Classes and Categories

• Eye Dam. 1 (11.6%)
• Muta. 2 (11.6%)
• Carc. 2 (93%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.