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Atomfair (1,3-Dioxolan-2-ylmethyl)magnesium bromide C4H7BrMgO2 CAS 180675-22-3

(1,3-Dioxolan-2-ylmethyl)magnesium bromide (CAS No. 180675-22-3) is a highly reactive Grignard reagent with the molecular formula C4H7BrMgO2. This organomagnesium compound is typically supplied as a 0.50 M solution in tetrahydrofuran (THF) , ensuring optimal stability and handling for synthetic applications. It features a 1,3-dioxolane-protected hydroxymethyl group , making it a versatile intermediate for nucleophilic additions, carbonyl alkylations, and other C-C bond-forming reactions. Ideal for organic synthesis, pharmaceutical research, and materials science , this reagent is rigorously quality-controlled to meet the demands of high-precision chemistry. Store under inert atmosphere (argon/nitrogen) at recommended temperatures to maintain reactivity.

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Description

(1,3-Dioxolan-2-ylmethyl)magnesium bromide (CAS No. 180675-22-3) is a highly reactive Grignard reagent with the molecular formula C4H7BrMgO2. This organomagnesium compound is typically supplied as a 0.50 M solution in tetrahydrofuran (THF), ensuring optimal stability and handling for synthetic applications. It features a 1,3-dioxolane-protected hydroxymethyl group, making it a versatile intermediate for nucleophilic additions, carbonyl alkylations, and other C-C bond-forming reactions. Ideal for organic synthesis, pharmaceutical research, and materials science, this reagent is rigorously quality-controlled to meet the demands of high-precision chemistry. Store under inert atmosphere (argon/nitrogen) at recommended temperatures to maintain reactivity.

Properties

  • CAS Number: 180675-22-3
  • Complexity: 47.3
  • IUPAC Name: magnesium;2-methanidyl-1,3-dioxolane;bromide
  • InChI: InChI=1S/C4H7O2.BrH.Mg/c1-4-5-2-3-6-4;;/h4H,1-3H2;1H;/q-1;;+2/p-1
  • InChI Key: IERSPCAGKAOLSQ-UHFFFAOYSA-M
  • Exact Mass: 189.94798
  • Molecular Formula: C4H7BrMgO2
  • Molecular Weight: 191.31
  • SMILES: [CH2-]C1OCCO1.[Mg+2].[Br-]
  • Topological: 18.5
  • Monoisotopic Mass: 189.94798
  • Synonyms: (1,3-dioxolan-2-ylmethyl)magnesium bromide, 629-669-2, 180675-22-3, Magnesium,bromo(1,3-dioxolan-2-ylmethyl)-, 1,3-Dioxolan-2-ylmethylmagnesium bromide, 0.50 M in THF, MFCD01321271, 2-[(bromomagnesio)methyl]-1,3-dioxolane, 1,3-Dioxolan-2-ylmethylmagnesium bromide, 0.50 M in 2-MeTHF, Magnesium, bromo(1,3-dioxolan-2-ylmethyl)-, SCHEMBL285800, ZDNTZRAFJZERSL-UHFFFAOYSA-M, AKOS015909032, 1,3-Dioxolan-2-ylmethylmagnesium bromide, ((1,3-dioxolan-2-yl)methyl)magnesium bromide, (1,3-Dioxolan-2-ylmethyl)magnesium bromide, 0.50 M in THF

Application

(1,3-Dioxolan-2-ylmethyl)magnesium bromide is widely used in organic synthesis for the preparation of complex molecules via nucleophilic addition to aldehydes, ketones, and esters. It serves as a key intermediate in pharmaceutical manufacturing, particularly for introducing protected hydroxymethyl groups into drug scaffolds. The reagent also finds utility in polymer chemistry for modifying functional groups in specialty monomers.

Safety and Hazards

GHS Hazard Statements

  • H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

  • P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

  • Skin Corr. 1B (100%)

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Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

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Certain molecules may be protected by active patents or regulatory restrictions.

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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