Description

1,3-dimethyl-1H-pyrazol-4-amine hydrochloride (CAS No. 1147222-02-3) is a high-purity organic compound with the molecular formula C₅H₁₀ClN₃. This hydrochloride salt derivative of 1,3-dimethyl-1H-pyrazol-4-amine is a versatile intermediate in pharmaceutical and agrochemical research. It is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring consistent performance in synthetic applications. The product is rigorously tested for identity (NMR, IR), potency, and impurities (residual solvents, heavy metals) to meet the stringent requirements of research and industrial applications. Suitable for use in medicinal chemistry, combinatorial synthesis, and as a building block for heterocyclic scaffolds.

Properties

• CAS Number: 1147222-02-3
• Complexity: 83.7
• IUPAC Name: 1,3-dimethylpyrazol-4-amine;hydrochloride
• InChI: InChI=1S/C5H9N3.ClH/c1-4-5(6)3-8(2)7-4;/h3H,6H2,1-2H3;1H
• InChI Key: ZDOGXPGAEYKUJK-UHFFFAOYSA-N
• Exact Mass: 147.0563250
• Molecular Formula: C5H10ClN3
• Molecular Weight: 147.60
• SMILES: CC1=NN(C=C1N)C.Cl
• Topological: 43.8
• Monoisotopic Mass: 147.0563250
• Synonyms: 1,3-dimethyl-1H-pyrazol-4-amine hydrochloride, 802-458-4, 1147222-02-3, 1,3-dimethylpyrazol-4-amine;hydrochloride, 1,3-DIMETHYL-1H-PYRAZOL-4-AMINE HCL, 4-Amino-1,3-dimethyl-1H-pyrazole hydrochloride, 1H-Pyrazol-4-amine, 1,3-dimethyl-, hydrochloride (1:1), 1,3-dimethylpyrazol-4-amine hydrochloride, MFCD02253769, 1,3-DIMETHYL-1H-PYRAZOL-4-YLAMINE HYDROCHLORIDE, SCHEMBL1557971, DTXSID10506902, ZDOGXPGAEYKUJK-UHFFFAOYSA-N, 1,3-Dimethylpyrazol-4-amine HCl, XVB22202, CL3439, AKOS004107406, AB89890, PS-8933, 1,3-dimethyl-pyrazol-4-amine hydrochloride, DB-097722, CS-0141734, 1,3-dimethyl-1H-pyrazol-4-aminehydrochloride, EN300-155587, Z1742055027, 1,3-Dimethyl-1H-pyrazol-4-amine–hydrogen chloride (1/1)

This compound serves as a key intermediate in the synthesis of biologically active molecules, particularly in drug discovery targeting kinase inhibition and CNS disorders. It is utilized in the preparation of pyrazole-based ligands for metalloenzyme studies and as a precursor for functionalized heterocycles in agrochemical development. Researchers employ it in cross-coupling reactions and as a nucleophile in SNAr transformations.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.