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Atomfair 1,3-Difluorobenzene m-DFB C6H4F2 CAS 372-18-9

1,3-Difluorobenzene (CAS No. 372-18-9) is a high-purity aromatic compound with the molecular formula C6H4F2, widely utilized in organic synthesis and material science. This colorless liquid, also known as m-Difluorobenzene , exhibits excellent chemical stability and serves as a versatile building block for pharmaceuticals, agrochemicals, and specialty polymers. With a boiling point of approximately 82-84°C and a density of 1.16 g/cm3, it is optimized for precision reactions including nucleophilic aromatic substitution and cross-coupling methodologies. Packaged under inert gas to ensure longevity, our ≥99% HPLC-grade product is ideal for demanding research applications. Available in quantities from 1g to 10kg with optional certificates…

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Description

1,3-Difluorobenzene (CAS No. 372-18-9) is a high-purity aromatic compound with the molecular formula C6H4F2, widely utilized in organic synthesis and material science. This colorless liquid, also known as m-Difluorobenzene, exhibits excellent chemical stability and serves as a versatile building block for pharmaceuticals, agrochemicals, and specialty polymers. With a boiling point of approximately 82-84°C and a density of 1.16 g/cm3, it is optimized for precision reactions including nucleophilic aromatic substitution and cross-coupling methodologies. Packaged under inert gas to ensure longevity, our ≥99% HPLC-grade product is ideal for demanding research applications. Available in quantities from 1g to 10kg with optional certificates of analysis (CoA).

Properties

  • CAS Number: 372-18-9
  • Complexity: 64.9
  • IUPAC Name: 1,3-difluorobenzene
  • InChI: InChI=1S/C6H4F2/c7-5-2-1-3-6(8)4-5/h1-4H
  • InChI Key: UEMGWPRHOOEKTA-UHFFFAOYSA-N
  • Exact Mass: 114.02810645
  • Molecular Formula: C6H4F2
  • Molecular Weight: 114.09
  • SMILES: C1=CC(=CC(=C1)F)F
  • Monoisotopic Mass: 114.02810645
  • Synonyms: 1,3-DIFLUOROBENZENE, m-Difluorobenzene, 2,4-difluorobenzene, meta-Difluorobenzene, 1,3-Difluorbenzol, UNII-VO3C26WOC2, EINECS 206-746-5, VO3C26WOC2, NSC 10285, NSC-10285, 1,3-BISFLUOROBENZENE, CHEBI:38584, DTXSID50190682, DTXCID90113173, uemgwprhooekta-uhfffaoysa-n, 372-18-9, Benzene, 1,3-difluoro-, Benzene, m-difluoro-, MFCD00000327, 1,3difluorobenzene, 1,3 difluorobenzene, 2,6-difluorobenzene, Benzene,3-difluoro-, 1,3-difluoro-benzene, WLN: FR CF, SCHEMBL3465, SCHEMBL4017, SCHEMBL13329, SCHEMBL26652, SCHEMBL221630, SCHEMBL1510165, SCHEMBL6719941, SCHEMBL19458402, 1,3-Difluorobenzene, >=99%, NSC10285, AKOS000119939, FD31678, PS-11965, DB-019928, DB-049081, D1626, NS00042186, EN300-19453, Q27117910, F0001-1068

Application

1,3-Difluorobenzene is a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly kinase inhibitors and antifungal agents. Its meta-substituted fluorine atoms enable regioselective functionalization in palladium-catalyzed coupling reactions. The compound is also employed in liquid crystal and polymer production, where its rigid benzene core enhances thermal stability. Researchers value its role in developing 19F NMR probes for biochemical studies.

Safety and Hazards

GHS Hazard Statements

  • H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
  • H319 (15.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (74.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

  • P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P317, P337+P317, P370+P378, P403+P235, and P501

Hazard Classes and Categories

  • Flam. Liq. 2 (100%)
  • Eye Irrit. 2 (15.5%)
  • Acute Tox. 4 (74.1%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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