Description

1,3-Dichloro-5-fluorobenzene (CAS No. 1435-46-7) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃Cl₂F. This specialty chemical is characterized by its two chlorine substituents at the 1 and 3 positions and a fluorine at the 5 position on the benzene ring, offering unique reactivity for electrophilic aromatic substitution and cross-coupling reactions. Provided as a clear, colorless to pale yellow liquid (or crystalline solid below 20°C), it is extensively used as a key intermediate in pharmaceutical synthesis, agrochemical production, and advanced material science. Our product is rigorously tested to meet ≥98% purity (GC) with controlled moisture content (<0.1% water) and is packaged under nitrogen in amber glass bottles to ensure stability. Ideal for Suzuki-Miyaura couplings, Buchwald-Hartwig aminations, and other palladium-catalyzed transformations.

Properties

• CAS Number: 1435-46-7
• Complexity: 87.1
• IUPAC Name: 1,3-dichloro-5-fluoro-benzene
• InChI: InChI=1S/C6H3Cl2F/c7-4-1-5(8)3-6(9)2-4/h1-3H
• InChI Key: BLWGKIXZAUOECS-UHFFFAOYSA-N
• Exact Mass: 163.9595836
• Molecular Formula: C6H3Cl2F
• Molecular Weight: 164.99
• SMILES: C1=C(C=C(C=C1Cl)Cl)F
• Monoisotopic Mass: 163.9595836
• Synonyms: 1,3-Dichloro-5-fluorobenzene, 670-878-3, 3,5-Dichlorofluorobenzene, 1435-46-7, Benzene, 1,3-dichloro-5-fluoro-, 3,5-Dichloro-1-fluorobenzene, Benzene,1,3-dichloro-5-fluoro-, MFCD00060652, 1,3-dichloro-5-fluoro-benzene, SCHEMBL260879, SCHEMBL261753, SCHEMBL1155869, DTXSID70162442, 1,3-Dichloro-5-fluorobenzene #, SBB087866, AKOS005063685, CS-W016079, AC-26084, CS-12137, SY038278, DB-022035, D4046, EN300-97594

Application

1,3-Dichloro-5-fluorobenzene serves as a versatile building block in medicinal chemistry for constructing trifunctionalized aromatic scaffolds in kinase inhibitors and CNS-active compounds. In material science, it acts as a precursor for liquid crystals and flame-retardant polymers through nucleophilic aromatic substitution reactions. The compound’s asymmetric halogen pattern enables selective functionalization in multi-step synthesis of crop protection agents.

Safety and Hazards

GHS Hazard Statements

• H225 (25%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H226 (75%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P264, P264+P265, P280, P302+P352, P303+P361+P353, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (25%)
• Flam. Liq. 3 (75%)
• Skin Irrit. 2 (75%)
• Eye Irrit. 2A (75%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.