Description

Description

1,3-Dichloro-5-fluorobenzene (CAS No. 1435-46-7) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃Cl₂F. This specialty chemical is characterized by its two chlorine substituents at the 1 and 3 positions and a fluorine at the 5 position on the benzene ring, offering unique reactivity for electrophilic aromatic substitution and cross-coupling reactions. Provided as a clear, colorless to pale yellow liquid (or crystalline solid below 20??C), it is extensively used as a key intermediate in pharmaceutical synthesis, agrochemical production, and advanced material science. Our product is rigorously tested to meet ??98% purity (GC) with controlled moisture content (<0.1% water) and is packaged under nitrogen in amber glass bottles to ensure stability. Ideal for Suzuki-Miyaura couplings, Buchwald-Hartwig aminations, and other palladium-catalyzed transformations.

Application

1,3-Dichloro-5-fluorobenzene serves as a versatile building block in medicinal chemistry for constructing trifunctionalized aromatic scaffolds in kinase inhibitors and CNS-active compounds. In material science, it acts as a precursor for liquid crystals and flame-retardant polymers through nucleophilic aromatic substitution reactions. The compound’s asymmetric halogen pattern enables selective functionalization in multi-step synthesis of crop protection agents.

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