Description

1,2,4,5-Tetrafluorobenzene (CAS No. 327-54-8) is a high-purity fluorinated aromatic compound with the molecular formula C₆H₂F₄. This specialty chemical is widely utilized in organic synthesis, pharmaceutical intermediates, and advanced material research due to its unique electronic and steric properties. The compound features a benzene ring substituted with four fluorine atoms at the 1, 2, 4, and 5 positions, offering enhanced reactivity and stability under harsh conditions. Our product is rigorously tested to ensure ≥98% purity (GC), with trace moisture and impurities minimized for sensitive applications. Available in sealed glass ampoules or custom bulk quantities, it is ideal for researchers requiring precise fluorination reactions or dielectric fluid development.

Key Specifications:
– CAS: 327-54-8
– Molecular Weight: 150.07 g/mol
– Boiling Point: 90-92°C
– Melting Point: 3-5°C
– Density: 1.443 g/cm³ at 25°C

Properties

• CAS Number: 327-54-8
• Complexity: 90.3
• IUPAC Name: 1,2,4,5-tetrafluorobenzene
• InChI: InChI=1S/C6H2F4/c7-3-1-4(8)6(10)2-5(3)9/h1-2H
• InChI Key: SDXUIOOHCIQXRP-UHFFFAOYSA-N
• Exact Mass: 150.00926271
• Molecular Formula: C6H2F4
• Molecular Weight: 150.07
• SMILES: C1=C(C(=CC(=C1F)F)F)F
• Monoisotopic Mass: 150.00926271
• Synonyms: 1,2,4,5-TETRAFLUOROBENZENE, 327-54-8, Benzene, 1,2,4,5-tetrafluoro-, 2,3,5,6-Tetrafluorobenzene, EINECS 206-319-3, DTXSID90186367, NSC 10249, DTXCID00108858, 206-319-3, sdxuioohciqxrp-uhfffaoysa-n, MFCD00000307, 1,2,4,5-tetrafluoro-benzene, NSC-10249, 2,3,5,6-Tetrafluorobenzene;p-Tetrafluorobenzene, 2,3,5,6-Tetrafluorobenzene;NSC 10249;p-Tetrafluorobenzene;, NSC10249, PHENYL, 2,3,5,6-TETRAFLUORO-, AB3CL8US2H, 1,4,5-Tetrafluorobenzene, 2,5,6-Tetrafluorobenzene, SCHEMBL78459, Benzene,2,4,5-tetrafluoro-, SCHEMBL415721, SCHEMBL530766, 2,3,5,6-tetrafluoro benzene, 1, 2, 4, 5-tetrafluorobenzene, DTXSID401309196, SBB086682, 1,2,4,5-tetrakis(fluoranyl)benzene, AKOS006223912, GS-3490, s10424, 1,2,4,5-Tetrafluorobenzene, >=99%, 92511-33-6, AC-10613, DB-018726, CS-0020157, NS00041536, T1029, EN300-97145, A821398, Z1203162141

Application

1,2,4,5-Tetrafluorobenzene serves as a critical building block in the synthesis of liquid crystals, agrochemicals, and pharmaceutical compounds where fluorinated aromatics enhance bioavailability. Its electron-deficient ring structure makes it valuable in Suzuki-Miyaura cross-coupling reactions for creating complex fluorinated scaffolds. The compound is also employed as a precursor for polymers with low dielectric constants in electronic materials, and as a solvent modifier in specialty chemical formulations requiring inert fluorinated media.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.