Description

1,2-Dimethoxyethane (DME), also known as Ethylene glycol dimethyl ether or Monoglyme, is a high-purity, versatile organic solvent with the molecular formula C₄H₁₀O₂ (CAS No. 110-71-4). This colorless, low-viscosity liquid exhibits excellent solvation properties for polar and nonpolar compounds, making it ideal for electrochemical, pharmaceutical, and synthetic applications. With a high boiling point (85°C) and moderate polarity, it serves as a key solvent in Grignard reactions, lithium-ion battery electrolytes, and polymer synthesis. Our product is available in multiple purity grades (≥99.0%, anhydrous, HPLC-grade) with optional inhibitor-free formulations to meet stringent laboratory and industrial requirements. Packaged under inert gas to prevent peroxide formation, it is supplied in amber glass bottles or bulk containers with certified analytical data (GC, water content, peroxide testing).

Properties

• CAS Number: 110-71-4
• Complexity: 17.5
• IUPAC Name: 1,2-dimethoxyethane
• InChI: InChI=1S/C4H10O2/c1-5-3-4-6-2/h3-4H2,1-2H3
• InChI Key: XTHFKEDIFFGKHM-UHFFFAOYSA-N
• Exact Mass: 90.068079557
• Molecular Formula: C4H10O2
• Molecular Weight: 90.12
• SMILES: COCCOC
• Topological: 18.5
• Monoisotopic Mass: 90.068079557
• Physical Description: 1,2-dimethoxyethane appears as a liquid with a sharp odor. Less dense than water. Flash point 34 °F. Mildly toxic by ingestion and inhalation. Severely irritates skin and eyes. Vapors heavier than air. Used to make other chemicals.
• Color/Form: WATER-WHITE LIQUID
• Odor: SHARP ETHEREAL ODOR
• Boiling Point: 185 °F at 760 mmHg
• Melting Point: -72 °F
• Flash Point: 32 °F
• Solubility: greater than or equal to 100 mg/mL at 72 °F
• Density: 0.868 at 68 °F – Less dense than water; will float
• Vapor Density: 3.1 – Heavier than air; will sink
• Vapor Pressure: 40 mmHg at 51.3 °F ; 60 mmHg at 67.5 °F
• Autoignition Temperature: 395 °F
• Heat of Combustion: -12,020 BTU/LB= -6680 CAL/G= -279.7X10+5 JOULES/KG
• Heat of Vaporization: 134 BTU/LB= 74.6 CAL/G= 3.12X10+5 JOULES
• Surface Tension: 0.02461 N/m at 20 °C
• Refractive Index: INDEX OF REFRACTION: 1.3813 @ 20 °C/D, 1.3739 @ 24 °C/D
• Synonyms: 1,2-DIMETHOXYETHANE, 110-71-4, Ethylene glycol dimethyl ether, Glyme, Dimethyl Cellosolve, Dimethoxyethane, Ethane, 1,2-dimethoxy-, Glycol dimethyl ether, Hisolve MMM, Ethylene dimethyl ether, Ansul ether 121, 1,2-Dimethoxyethan, DME (glycol ether), Dimethylcellosolve, Monoethylene glycol dimethyl ether, 1,2-Ethanediol dimethyl ether, CH3OCH2CH2OCH3, Ethylenglycoldimethylether, Ethylenglykoldimethylether, .alpha.,.beta.-Dimethoxyethane, HSDB 73, NSC 60542, alpha,beta-Dimethoxyethane, UNII-GXS24JF5IW, GXS24JF5IW, EINECS 203-794-9, UN2252, BRN 1209237, DTXSID0025286, CHEBI:42263, AI3-61007, NSC-60542, DTXCID705286, DIMETHYOXYETHANE, 1,2-, EC 203-794-9, 1,2-DIMETHOXYETHANE [MI], 4-01-00-02376 (Beilstein Handbook Reference), 1,2-DIMETHOXYETHANE [HSDB], 1,2-DIMETHOXYETHANE [USP-RS], UN 2252, 1,2-DIMETHOXYETHANE (USP-RS), 2,5Dioxahexane, Ethane, 1,2dimethoxy, DME (SOLVENT), ANSUL ETHER 12′, 1,2Ethanediol dimethyl ether, DIMETHYL CELLOSOLVE SOLVENT, 1,2-ETHANEDIOL,DIMETHYL ETHER (DIMETHYLGLYCOL), inchi=1/c4h10o2/c1-5-3-4-6-2/h3-4h2,1-2h, xthfkediffgkhm-uhfffaoysa-n, Monoglyme, 2,5-Dioxahexane, Egdme, Dimethylglycol, 24991-55-7, Dimethyl Glycol, mono-Glyme, MFCD00008502, 1,2-dimethoxy-ethane, 1,2-dimethoxy ethane, Ethane-1,1,2,2-d4, 1,2-dimethoxy-, 1, 2-Dimethoxyethane, ASTM Method D4815/D5599 1,2-Dimethoxyethane IS, dimetoxyethane, ethyleneglycol dimethyl ether, Dimethoxyethan, Selexol, 1,2dimethoxyethane, 1,2 dimethoxyethan, 1,2-dimethoxyetane, 1,2-dimetoxyethane, Genosorb 175, Genosorb 300, 1,2 dimethoxyethane, 1,2-dimethoxiethane, 1,2~dimethoxyethane, 1.2-dimethoxyethane, Varonic DM 55, Ethane,2-dimethoxy-, 1,2 dimethoxyetharie, 1,2 dimethoxylethane, 1,2-dimethoxylethane, 1,2-dimethyoxyethane, Glyme-23, Sanfine DM 200, Sanfine DM 400, 1,2-dimethyloxyethane, 1,2 -dimethoxyethane, 1,2,-dimethoxyethane, 1,2- dimethoxyethane, 1,2-di-methoxyethane, 1,2-dimethoxye-thane, PEG-6 dimethyl ether, PEG-7 dimethyl ether, PEG-8 dimethyl ether, PEG-9 dimethyl ether, Sanfine DM 1000, Carpol CLE 1000, 1,2 -dimethoxy ethane, PEG-10 dimethyl ether, UNII-OMW34MPM4E, Nissan Unisafe MM 400, OMW34MPM4E, 1,2-bis(methyloxy)ethane, UNII-O5E08Z8AEA, UNII-W83S1I1CJE, Nissan Unisafe MM 1000, SCHEMBL1154, SCHEMBL2723, ethylene glycol dimethylether, U-Nox DM 200, O5E08Z8AEA, UNII-7GSD980LF9, UNII-9I2Z48JZJ5, W83S1I1CJE, (2-methoxy)ethylmethyl ether, U-Nox DM 1000, ethylene-glycol dimethyl ether, SCHEMBL113934, SCHEMBL731014, 7GSD980LF9, 9I2Z48JZJ5, PEG-DME 2000, SCHEMBL4072491, SCHEMBL4512521, SCHEMBL8755245, 1,2-Dimethoxyethane, anhydrous, monoethylene glycol dimethylether, CHEMBL1232411, dimethylene glycol dimethyl ether, SCHEMBL10297341, SCHEMBL10297350, BCP30022, NSC60542, Tox21_200420, STL282726, AKOS009029143, DB01749, SB13076, 1,2-Dimethoxyethane, purification grade, 1,2-Dimethoxyethane, analytical standard, NCGC00248602-01, NCGC00257974-01, Poly(ethylene glycol) dimethyl ether NHD, CAS-110-71-4, FP106433, PD008450, 1,2-Dimethoxyethane, low water =99.0%, A802238, Q416271, 1,2-Dimethoxyethane [UN2252] [Flammable liquid], Ethylene glycol dimethyl ether (1,2-Dimethoxyethane), 1,2-Dimethoxyethane, anhydrous, 99.5%, inhibitor-free, 1,2-Dimethoxyethane, for HPLC, 99.9%, inhibitor-free, 1,2-ETHANEDIOL,DIMETHYL ETHER (DIMETHYLGLYCOL), F1908-0122, 1,2-Dimethoxyethane, ReagentPlus(R), >=99%, inhibitor-free, 1,2-Dimethoxyethane, anhydrous, inhibitor-free, ZerO2(TM), 99.5%, ASTM D4815 Quantitative Peak ID Mixture 4.00-7.30 % (w/w), Ethylene dimethyl ether;1,2-dimethoxy-ethan;Ethylene glycol dimethyl ether

1,2-Dimethoxyethane is widely used as an aprotic solvent in organometallic chemistry, particularly for Grignard and lithiation reactions. It serves as a co-solvent in lithium-ion battery electrolytes due to its stability with lithium salts and wide electrochemical window. In pharmaceuticals, it aids in crystallization and as a reaction medium for APIs. Additionally, it functions as a solvent for resins, dyes, and cellulose derivatives.

Safety and Hazards

GHS Hazard Statements

• H225: Highly Flammable liquid and vapor [Danger Flammable liquids]
• H332: Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
• H360: May damage fertility or the unborn child [Danger Reproductive toxicity]
• H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P303+P361+P353, P304+P340, P317, P318, P319, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (99.8%)
• Skin Irrit. 2 (44.8%)
• Acute Tox. 4 (84.4%)
• Carc. 2 (10.5%)
• Repr. 1B (85.8%)
• Repr. 1B (14.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.