Description

1,2-Difluorobenzene (CAS No. 367-11-3) is a high-purity aromatic compound with the molecular formula C₆H₄F₂, widely utilized in organic synthesis and material science. This colorless liquid, also known as o-difluorobenzene, features two fluorine atoms substituted at the 1 and 2 positions of the benzene ring, imparting unique electronic and steric properties. With a boiling point of ~92°C and a density of 1.16 g/cm³, it serves as a versatile building block for pharmaceuticals, agrochemicals, and specialty polymers. Packaged under inert gas to ensure stability, our ≥98% purity grade is ideal for precision applications. Compatible with Grignard reactions, cross-coupling, and fluorination processes. Available in sealed glass ampules or bulk quantities with GC/MS certification.

Properties

• CAS Number: 367-11-3
• Complexity: 62.9
• IUPAC Name: 1,2-difluorobenzene
• InChI: InChI=1S/C6H4F2/c7-5-3-1-2-4-6(5)8/h1-4H
• InChI Key: GOYDNIKZWGIXJT-UHFFFAOYSA-N
• Exact Mass: 114.02810645
• Molecular Formula: C6H4F2
• Molecular Weight: 114.09
• SMILES: C1=CC=C(C(=C1)F)F
• Monoisotopic Mass: 114.02810645
• Physical Description: Colorless liquid; Not miscible or difficult to mix in water;
• Synonyms: 1,2-DIFLUOROBENZENE, o-Difluorobenzene, Benzene, 1,2-difluoro-, Benzene, o-difluoro-, ortho-Difluorobenzene, AW7QGMW29C, EINECS 206-680-7, NSC 10275, 1,2-Difluorbenzol, BRN 1905113, AI3-52226, UNII-AW7QGMW29C, NSC-10275, DTXSID2075390, CHEBI:38583, 4-05-00-00637 (Beilstein Handbook Reference), oDifluorobenzene, Benzene, odifluoro, Benzene, 1,2difluoro, DTXCID1039216, 206-680-7, goydnikzwgixjt-uhfffaoysa-n, inchi=1/c6h4f2/c7-5-3-1-2-4-6(5)8/h1-4, 367-11-3, 1,2-difluoro-benzene, difluorobenzene, MFCD00000284, 0-difluorobenzene, Benzene,2-difluoro-, 1,2-bis(fluoranyl)benzene, SCHEMBL3991, SCHEMBL45406, SCHEMBL57893, 1,2-Difluorobenzene, 98%, 10-27-5, SCHEMBL169196, SCHEMBL5167456, SCHEMBL7101339, SCHEMBL16464760, BCP25286, NSC10275, AKOS000120159, FD46280, PS-11966, D1627, NS00041708, EN300-19236, A823337, Q425257, F0001-1048, Z104473256, (3R pound not4R)-3-hydroxy-3 pound not4-bis[(4-hydroxy-3-methoxy-phenyl)methyl]oxolan-2- one

Application

1,2-Difluorobenzene is a key intermediate in synthesizing fluorinated liquid crystals for advanced display technologies. It acts as a precursor in pharmaceutical manufacturing, particularly for bioactive molecules with enhanced metabolic stability. Researchers also employ it as a solvent or reagent in nucleophilic aromatic substitution reactions. Its electron-withdrawing properties make it valuable in designing organic semiconductors and OLED materials.

Safety and Hazards

GHS Hazard Statements

• H225 (98.2%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H314 (24.8%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (98.2%)
• Skin Corr. 1B (24.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.