Description

1,2-Difluoro-4-nitrobenzene (CAS No. 369-34-6) is a high-purity aromatic compound with the molecular formula C₆H₃F₂NO₂. This fluorinated nitrobenzene derivative is characterized by its two fluorine atoms at the 1- and 2-positions and a nitro group at the 4-position of the benzene ring, offering unique reactivity for electrophilic substitution and nucleophilic aromatic substitution (SNAr) reactions. It is supplied as a crystalline solid with a purity of ≥98%, ideal for synthetic organic chemistry, pharmaceutical intermediates, and agrochemical research. Suitable for use in Suzuki coupling, Ullmann reactions, and as a precursor for advanced materials. Store in a cool, dry place away from light and oxidizing agents.

Properties

• CAS Number: 369-34-6
• Complexity: 159
• IUPAC Name: 1,2-difluoro-4-nitro-benzene
• InChI: InChI=1S/C6H3F2NO2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H
• InChI Key: RUBQQRMAWLSCCJ-UHFFFAOYSA-N
• Exact Mass: 159.01318466
• Molecular Formula: C6H3F2NO2
• Molecular Weight: 159.09
• SMILES: C1=CC(=C(C=C1[N+](=O)[O-])F)F
• Topological: 45.8
• Monoisotopic Mass: 159.01318466
• Synonyms: 3,4-Difluoronitrobenzene, 1,2-Difluoro-4-nitrobenzene, RUBQQRMAWLSCCJ-UHFFFAOYSA-, 206-718-2, inchi=1/c6h3f2no2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3h, 369-34-6, Benzene, 1,2-difluoro-4-nitro-, 3,4-difluoro-1-nitrobenzene, 1,2-difluoro-4-nitro-benzene, MFCD00007198, 1-Nitro-3,4-difluorobenzene, BRN 1944996, EINECS 206-718-2, 3,4-Difluoro nitrobenzene, 1,2-Difluoro-4-nitrobenzene; 3,4-Difluoronitrobenzene; 4-Nitro-1,2-difluorobenzene, 3,4-difluornitrobenzene, 3.4-difluoronitrobenzene, 3, 4-difluoronitrobenzene, 3,4-difluoro-nitrobenzene, 3,4- Difluoronitrobenzene, 3, 4-difluoro nitrobenzene, 3,4-difluoro-nitro benzene, 3,4-difluoro-nitro-benzene, B3RMA758VG, SCHEMBL85604, SCHEMBL147156, 3,4-difluoro-1-nitro-benzene, SCHEMBL4577560, 3,4-Difluoronitrobenzene, 99%, DTXSID00190379, 3 pound not4-Difluoronitrobenzene, SBB063046, AKOS005258669, AKOS015888122, CS-W016188, FD64616, HY-W015472, PB47436, AC-10117, AS-14509, DB-006279, D1926, NS00041731, ST51039900, EN300-36083, P16484, Z362626586, 1,2-Difluoro-4-nitrobenzene;1,2-Difluoro-4-nitrobenzene

Application

1,2-Difluoro-4-nitrobenzene is widely used as a versatile building block in organic synthesis, particularly in the preparation of fluorinated pharmaceuticals and agrochemicals. Its electron-deficient aromatic ring makes it a valuable substrate for SNAr reactions to introduce heteroatoms or functional groups. Researchers also utilize it in the development of liquid crystals, OLED materials, and specialty polymers. The compound’s nitro group can be reduced to an amine for further derivatization.

Safety and Hazards

GHS Hazard Statements

• H302 (14.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (12.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (12.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (10.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (14.9%)
• Acute Tox. 4 (12.8%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (12.8%)
• STOT SE 3 (97.9%)
• STOT RE 2 (10.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.