Description

1,2-Bis(2-chloroethoxy)ethane (CAS No. 112-26-5) is a high-purity organic compound with the molecular formula C₆H₁₂Cl₂O₂, widely used in research and industrial applications. This colorless to pale yellow liquid is also known as Triglycol dichloride or Triethylene glycol dichloride, offering excellent solvency and reactivity for synthetic chemistry. Its IUPAC name, 1,2-bis(2-chloroethoxy)ethane, reflects its symmetrical ether-chloride structure, making it a versatile intermediate for polymer synthesis, crosslinking agents, and specialty chemical manufacturing. With a molecular weight of 187.06 g/mol, it is compatible with organic solvents and exhibits moderate volatility. Ideal for controlled reactions, this compound is packaged under inert conditions to ensure stability and longevity. Suitable for laboratory R&D, pharmaceutical intermediates, and material science applications.

Properties

• CAS Number: 112-26-5
• Complexity: 53.7
• IUPAC Name: 1,2-bis(2-chloroethoxy)ethane
• InChI: InChI=1S/C6H12Cl2O2/c7-1-3-9-5-6-10-4-2-8/h1-6H2
• InChI Key: AGYUOJIYYGGHKV-UHFFFAOYSA-N
• Exact Mass: 186.0214350
• Molecular Formula: C6H12Cl2O2
• Molecular Weight: 187.06
• SMILES: C(COCCCl)OCCCl
• Topological: 18.5
• Monoisotopic Mass: 186.0214350
• Physical Description: Colorless liquid;
• Color/Form: Colorless liquid
• Boiling Point: 241.3 °C
• Melting Point: FP: -31.5 °C
• Flash Point: 250 °F; 121 °C
• Solubility: Soluble in carbon tetrachloride
• Density: 1.1974 @ 20 °C/20 °C
• Vapor Pressure: 0.06 [mmHg]
• Refractive Index: Index of refraction: 1.4592 @ 25 °C/D
• Synonyms: 1,2-BIS(2-CHLOROETHOXY)ETHANE, 112-26-5, Triglycol dichloride, Ethane, 1,2-bis(2-chloroethoxy)-, Triethylene glycol dichloride, 1,8-Dichloro-3,6-dioxaoctane, Bis(2-chloroethoxy)ethane, 1,2-Bis(chloroethoxy)ethane, 2-(2-Chloroethoxy)ethyl 2′-chloroethyl ether, Bis(chloroethoxy)ethane, 2-(2-Chlorethoxy)ethyl 2′-chlorethyl ether, 27252-69-3, DTXSID8047000, 1-Chloro-2-[2-(2-chloroethoxy)ethoxy]ethane, 28JQ82M13J, Ethylene Glycol Bis(2-chloroethyl) Ether, C6H12Cl2O2, Di(2-chloroethyl) Cellosolve, 2-chloro-1-[2-(2-chloroethoxy)ethoxy]ethane, HSDB 5400, EINECS 203-952-7, BRN 0506177, UNII-28JQ82M13J, AI3-28584, 1,2-bis-(2-Chloroethoxy)ethane, MFCD00000976, SCHEMBL44786, CHEMBL3188977, DTXCID6027000, AGYUOJIYYGGHKV-UHFFFAOYSA-, 1,2-bis(2-chloroethyloxy)ethane, 1,8-dichloro-3, 6-dioxaoctane, 1,2-bis-(2-chloro-ethoxy)-ethane, Tox21_302011, SBB059970, AKOS009031431, FT40732, 1,2-Bis(2-chloroethoxy)ethane, 97%, NCGC00256237-01, BS-22421, CAS-112-26-5, B0471, CS-0158308, NS00006522, ST51046234, EN300-19706, 1,2-BIS(2-CHLOROETHOXY)ETHANE [HSDB], E76650, A802531, Q27254323, InChI=1/C6H12Cl2O2/c7-1-3-9-5-6-10-4-2-8/h1-6H2

Application

1,2-Bis(2-chloroethoxy)ethane is primarily used as a reactive intermediate in organic synthesis, particularly for the preparation of crown ethers and polyethylene glycol derivatives. It serves as a crosslinking agent in polymer chemistry, enhancing material durability and thermal stability. Researchers also employ it in the development of specialty surfactants and phase-transfer catalysts due to its bifunctional reactivity. Its role in pharmaceutical intermediates and agrochemical formulations underscores its versatility in industrial applications.

Safety and Hazards

GHS Hazard Statements

• H301: Toxic if swallowed [Danger Acute toxicity, oral]
• H312: Harmful in contact with skin [Warning Acute toxicity, dermal]
• H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]
• H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P264, P270, P280, P301+P316, P302+P352, P308+P316, P317, P319, P321, P330, P362+P364, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (98.1%)
• Acute Tox. 4 (99.4%)
• Skin Irrit. 2 (94.9%)
• Eye Dam. 1 (26.3%)
• Eye Irrit. 2 (71.2%)
• STOT SE 3 (28.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.