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Atomfair 1,1,1-Trifluoro-N,N-dimethylmethanesulfonamide C3H6F3NO2S CAS 28048-17-1

1,1,1-Trifluoro-N,N-dimethylmethanesulfonamide (CAS No. 28048-17-1) is a high-purity fluorinated sulfonamide compound with the molecular formula C3H6F3NO2S . This specialty chemical is characterized by its trifluoromethyl and dimethylsulfonamide functional groups, making it a valuable reagent for advanced synthetic and catalytic applications. It is supplied as a clear, colorless to pale-yellow liquid with exceptional stability under inert conditions. Ideal for researchers in organofluorine chemistry, this compound serves as a versatile building block for pharmaceuticals, agrochemicals, and materials science. Strict quality control ensures ≥95% purity (GC), with detailed technical data available upon request. Store under nitrogen at 2-8°C to maintain optimal integrity.

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Description

1,1,1-Trifluoro-N,N-dimethylmethanesulfonamide (CAS No. 28048-17-1) is a high-purity fluorinated sulfonamide compound with the molecular formula C3H6F3NO2S. This specialty chemical is characterized by its trifluoromethyl and dimethylsulfonamide functional groups, making it a valuable reagent for advanced synthetic and catalytic applications. It is supplied as a clear, colorless to pale-yellow liquid with exceptional stability under inert conditions. Ideal for researchers in organofluorine chemistry, this compound serves as a versatile building block for pharmaceuticals, agrochemicals, and materials science. Strict quality control ensures ≥95% purity (GC), with detailed technical data available upon request. Store under nitrogen at 2-8°C to maintain optimal integrity.

Properties

  • CAS Number: 28048-17-1
  • Complexity: 199
  • IUPAC Name: 1,1,1-trifluoro-N,N-dimethyl-methanesulfonamide
  • InChI: InChI=1S/C3H6F3NO2S/c1-7(2)10(8,9)3(4,5)6/h1-2H3
  • InChI Key: GSIWUFBWQIELGP-UHFFFAOYSA-N
  • Exact Mass: 177.00713409
  • Molecular Formula: C3H6F3NO2S
  • Molecular Weight: 177.15
  • SMILES: CN(C)S(=O)(=O)C(F)(F)F
  • Topological: 45.8
  • Monoisotopic Mass: 177.00713409
  • Synonyms: 1,1,1-trifluoro-N,N-dimethylmethanesulfonamide, 881-285-6, 28048-17-1, N,N-DIMETHYLTRIFLUOROMETHANESULFONAMIDE, MFCD20366501, AI 3-10742, SCHEMBL1008667, DTXSID50182325, GSIWUFBWQIELGP-UHFFFAOYSA-N, AKOS013917522, AS-82789, SY204171, DB-421043, CS-0240020, E83651, EN300-222993, Methanesulfonamide, 1,1,1-trifluoro-N,N-dimethyl-

Application

1,1,1-Trifluoro-N,N-dimethylmethanesulfonamide is widely employed as a fluorinating agent and polar aprotic solvent in nucleophilic substitution reactions. Its strong electron-withdrawing properties make it effective in catalyzing Friedel-Crafts acylations and facilitating trifluoromethylation processes. Researchers utilize this compound in the synthesis of bioactive molecules, particularly in medicinal chemistry for introducing trifluoromethyl groups into heterocyclic scaffolds. It also finds niche applications in electrolyte formulations for lithium-ion batteries due to its thermal stability.

Safety and Hazards

GHS Hazard Statements

  • H226 (50%): Flammable liquid and vapor [Warning Flammable liquids]
  • H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H317 (50%): May cause an allergic skin reaction [Warning Sensitization, Skin]
  • H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
  • H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

  • P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P272, P280, P301+P317, P302+P352, P303+P361+P353, P305+P351+P338, P305+P354+P338, P317, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P403+P235, and P501

Hazard Classes and Categories

  • Flam. Liq. 3 (50%)
  • Acute Tox. 4 (50%)
  • Acute Tox. 4 (50%)
  • Skin Irrit. 2 (100%)
  • Skin Sens. 1 (50%)
  • Eye Dam. 1 (50%)
  • Eye Irrit. 2 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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