Description

1,1,1-Trifluoro-2-propanamine (CAS No. 421-49-8) is a high-purity fluorinated amine compound with the molecular formula C₃H₆F₃N. This specialty chemical is characterized by its trifluoromethyl group, which enhances its reactivity and stability in synthetic applications. It is supplied as a clear, colorless liquid with a molecular weight of 113.08 g/mol and is ideal for use in pharmaceutical intermediates, agrochemical synthesis, and advanced material research. The compound is rigorously tested for purity (typically ≥98%) and is packaged under inert conditions to ensure long-term stability. Suitable for researchers and industrial scientists seeking a versatile fluorinated building block.

Properties

• CAS Number: 421-49-8
• Complexity: 57.7
• IUPAC Name: 1,1,1-trifluoropropan-2-amine
• InChI: InChI=1S/C3H6F3N/c1-2(7)3(4,5)6/h2H,7H2,1H3
• InChI Key: SNMLKBMPULDPTA-UHFFFAOYSA-N
• Exact Mass: 113.04523368
• Molecular Formula: C3H6F3N
• Molecular Weight: 113.08
• SMILES: CC(C(F)(F)F)N
• Topological: 26
• Monoisotopic Mass: 113.04523368
• Synonyms: 1,1,1-trifluoropropan-2-amine, 421-49-8, 1,1,1-trifluoro-2-propanamine, DTXSID901307602, DTXCID60862964, 806-637-8, 2-Amino-1,1,1-trifluoropropane, MFCD04973020, 1-(Trifluoromethyl)ethylamine, 2,2,2-trifluoro-1-methylethylamine, (2R)-1,1,1-trifluoropropan-2-amine, 1,1,1-TRIFLUOROISOPROPYLAMINE, 1,1,1-Trifluoropropan-2-amine HCl, 1,1,1-Trifluoro-Isopropylamine, 2,2,2-Trifluoro-1-methyl-ethylamine, 1,1,1-trifluoro-2-propylamine, 2-Propanamine, 1,1,1-trifluoro-, (2,2,2-trifluoro-1-methylethyl)amine, SCHEMBL234663, SCHEMBL2079204, SCHEMBL2104013, SCHEMBL26961317, 49QD2666SS, ALBB-016753, BCP13911, 1-methyl-2,2,2-trifluoroethylamine, AKOS005762894, CS-W000651, SB75315, 2,2,2-trifluoro-1-methyl-ethyl-amine, AS-18654, SY035354, SY065364, L-2,2,2,-trifluoro-1-(methyl)ethylamine, CS-0022346, EN300-89604, N12201

Application

1,1,1-Trifluoro-2-propanamine is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its trifluoromethyl group imparts metabolic stability, making it valuable in drug discovery. The compound also serves as a precursor for specialty polymers and ligands in catalysis. Researchers leverage its unique reactivity for introducing fluorine into complex organic frameworks.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P319, P321, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Skin Corr. 1B (100%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.