Description

1,1,1-Trifluoro-2-iodoethane (CAS No. 353-83-3) is a highly specialized fluorinated organic compound with the molecular formula C₂H₂F₃I. This clear, volatile liquid is characterized by its trifluoromethyl group and reactive iodoethane moiety, making it a valuable intermediate in synthetic organic chemistry and pharmaceutical research. With a purity grade of ≥98%, our product is rigorously tested via GC-MS and NMR to ensure consistency for demanding applications. Ideal for nucleophilic substitution reactions, cross-coupling processes, and as a building block for fluorinated compounds, it is supplied in amber glass bottles under inert gas to prevent degradation. Store at 2-8°C in a well-ventilated area, away from light and moisture. Hazard statements apply (H315, H319, H335).

Properties

• CAS Number: 353-83-3
• Complexity: 38.5
• IUPAC Name: 1,1,1-trifluoro-2-iodo-ethane
• InChI: InChI=1S/C2H2F3I/c3-2(4,5)1-6/h1H2
• InChI Key: RKOUFQLNMRAACI-UHFFFAOYSA-N
• Exact Mass: 209.91533
• Molecular Formula: C2H2F3I
• Molecular Weight: 209.94
• SMILES: C(C(F)(F)F)I
• Monoisotopic Mass: 209.91533
• Synonyms: 1,1,1-Trifluoro-2-iodoethane, 2-Iodo-1,1,1-trifluoroethane, 2,2,2-Trifluoroethyl iodide, Trifluoroethyl iodide, 1,1,1-Trifluoroiodoethane, CF3CH2I, UNII-CA0J38WE9Z, EINECS 206-541-0, CA0J38WE9Z, 2,2,2-trifluoro-1-iodoethane, 1H,1H-Perfluoroethyl iodide, DTXSID80188810, DTXCID40111301, inchi=1/c2h2f3i/c3-2(4,5)1-6/h1h, rkoufqlnmraaci-uhfffaoysa-n, 353-83-3, Ethane, 1,1,1-trifluoro-2-iodo-, 1-Iodo-2,2,2-trifluoroethane, 1,1,1-trifluoro-2-iodo-ethane, MFCD00001082, Ethane,1,1,1-trifluoro-2-iodo-, 2,2,2-trifluoroiodoethane, C2H2F3I, iodotrifluoroethane, trifluoroiodoethane, 1-Iodo-2,2,2-trifluoroethane; 2,2,2-Trifluoro-1-iodoethane; 2,2,2-Trifluoroethyl Iodide; 2,2,2-Trifluoroiodoethane; 2-Iodo-1,1,1-trifluoroethane;, trifluoro ethyl iodide, ICH2CF3, 2,2,2-trifluoroethyliodide, SCHEMBL30918, 2,2,2,-trifluoroethyl iodide, 2,2,2-trifluoro-ethyl iodide, 1,1,1-trifiuoro-2-iodoethane, 2-iodo-1,1,1 trifluoroethane, SCHEMBL10958059, 2-iodo-1,1,1-trifluoroethaane, 2-iodo-1,1,1,-trifluoroethane, 2-iodo-1,1,1-trifluoro-ethane, CS-D1740, FD2058, SBB094272, AKOS005258207, FS-4196, 1,1,1-Trifluoro-2-iodoethane, 99%, BP-12693, SY001054, DB-028115, NS00041425, T1148, EN300-91258, 1,1,1-Trifluoro-2-iodoethane Trifluoroethyl iodide, Q27275372, 2,2,2-Trifluoroethyl iodide, 2-Iodo-1,1,1-trifluoroethane

Application

1,1,1-Trifluoro-2-iodoethane serves as a key reagent in the synthesis of fluorinated pharmaceuticals and agrochemicals, enabling the introduction of trifluoroethyl groups via cross-coupling reactions. It is widely used in palladium-catalyzed transformations, such as Heck and Suzuki couplings, to construct complex fluorinated architectures. Researchers also employ it as a precursor for radiolabeling compounds in PET imaging studies due to the lability of the iodine moiety.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.