Description

1-Trityl-1H-imidazole-4-carboxylic acid (CAS No. 191103-80-7) is a high-purity organic compound with the molecular formula C₂₃H₁₈N₂O₂. This specialized chemical features a trityl-protected imidazole core with a carboxylic acid functional group, making it a valuable intermediate in synthetic organic chemistry and pharmaceutical research. The compound is characterized by its white to off-white crystalline appearance and is supplied with comprehensive analytical data including ¹H NMR, ¹³C NMR, and HPLC purity reports. With a molecular weight of 354.41 g/mol, this reagent is particularly useful in peptide synthesis and heterocyclic chemistry applications. Store in a cool, dry place under inert atmosphere for maximum stability.

Properties

• CAS Number: 191103-80-7
• Complexity: 445
• IUPAC Name: 1-tritylimidazole-4-carboxylic acid
• InChI: InChI=1S/C23H18N2O2/c26-22(27)21-16-25(17-24-21)23(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-17H,(H,26,27)
• InChI Key: UQQHMXJCLHSYRV-UHFFFAOYSA-N
• Exact Mass: 354.136827821
• Molecular Formula: C23H18N2O2
• Molecular Weight: 354.4
• SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=C(N=C4)C(=O)O
• Topological: 55.1
• Monoisotopic Mass: 354.136827821
• Synonyms: 1-Trityl-1H-imidazole-4-carboxylic acid, 191103-80-7, 1-tritylimidazole-4-carboxylic Acid, 1H-Imidazole-4-carboxylic acid, 1-(triphenylmethyl)-, 1-(Triphenylmethyl)-1H-imidazole-4-carboxylic acid, MFCD06203351, SCHEMBL670904, DTXSID60441910, UQQHMXJCLHSYRV-UHFFFAOYSA-N, ALBB-034189, N-tritylimidazole-4-carboxylic acid, AKOS015839039, 1-trityl -1H-imidazole-4-formic acid, 1-Trityl-1H-imidazole-4-carboxylicacid, BS-21972, 1-Trityl-1 H-imidazole-4-carboxylic acid, DB-065736, CS-0186371, D97356

Application

1-Trityl-1H-imidazole-4-carboxylic acid serves as a key building block in medicinal chemistry for the synthesis of imidazole-containing drug candidates. The trityl protecting group enables selective functionalization of the imidazole ring system during multi-step syntheses. Researchers utilize this compound in the development of enzyme inhibitors and receptor modulators targeting various biological pathways. Its carboxylic acid moiety allows for further derivatization through standard coupling reactions.

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