Description

1-(Trifluoromethyl)cyclopropane-1-carboxylic acid (CAS No. 277756-46-4) is a high-purity fluorinated organic compound with the molecular formula C₅H₅F₃O₂. This specialty chemical features a cyclopropane ring substituted with a trifluoromethyl group and a carboxylic acid functionality, making it a valuable intermediate in pharmaceutical, agrochemical, and materials science research. Its unique structural properties enable applications in the synthesis of bioactive molecules, fluorinated polymers, and advanced materials. The product is supplied as a white to off-white crystalline solid with a purity of ≥97%, ensuring consistent performance in demanding synthetic workflows. Store in a cool, dry place away from light and moisture to maintain stability.

Properties

• CAS Number: 277756-46-4
• Complexity: 168
• IUPAC Name: 1-(trifluoromethyl)cyclopropanecarboxylic acid
• InChI: InChI=1S/C5H5F3O2/c6-5(7,8)4(1-2-4)3(9)10/h1-2H2,(H,9,10)
• InChI Key: SKCBKBCACWDALV-UHFFFAOYSA-N
• Exact Mass: 154.02416388
• Molecular Formula: C5H5F3O2
• Molecular Weight: 154.09
• SMILES: C1CC1(C(=O)O)C(F)(F)F
• Topological: 37.3
• Monoisotopic Mass: 154.02416388
• Synonyms: 277756-46-4, 1-(Trifluoromethyl)cyclopropane-1-carboxylic acid, 1-(trifluoromethyl)cyclopropanecarboxylic acid, DTXSID80380857, DTXCID60331882, 629-220-0, 1-Trifluoromethylcyclopropane-1-carboxylic acid, CYCLOPROPANECARBOXYLIC ACID, 1-(TRIFLUOROMETHYL)-, 1-trifluoromethylcyclopropanecarboxylic acid, 1-(Trifluoromethyl)cyclopropane-1-carboxylicacid, MFCD03093070, C5H5F3O2, 1-(Trifluoromethyl)cyclopropanecarboxylicacid, 1-TRIFLUOROMETHYLCYCLOPROPANE-1-CARBOXYLICACID, 1-(trifluoromethyl)-1-cyclopropanecarboxylic acid, SCHEMBL18559, SCHEMBL22572567, BCP05999, BBL034865, SBB086959, STL419682, AKOS005063378, AB13199, FT28486, PS-6587, Trifluoromethyl-cyclopropanecarboxylic acid, 1-trifluormethyl-cyclopropanecarboxylic acid, DB-001165, Trifluoromethyl cyclopropane carboxylic acid, 1-trifluoromethyl-cyclopropanecarboxylic acid, CS-0020140, ST45021950, T3765, 1-trifluoromethyl-cyclopropane carboxylic acid, EN300-64916, 1-(trifluoromethyl)-cyclopropanecarboxylic acid, 1-(trifluoromethyl)cyclopropane carboxylic acid, 1-(trifluoromethyl)cyclopropan-1-carboxylic acid, 1-(Trifluoromethyl)cyclopropane-1-carboxylic acid, 97%, F8880-1073, 1-(Trifluoromethyl)cyclopropanecarboxylic acid;1-Trifluoromethyl-cyclopropanecarboxylic acid

1-(Trifluoromethyl)cyclopropane-1-carboxylic acid is widely used as a key building block in medicinal chemistry for the synthesis of trifluoromethylated drug candidates. It serves as a precursor for fluorinated agrochemicals, enhancing metabolic stability and bioavailability. The compound is also employed in materials science to modify polymer properties such as hydrophobicity and thermal resistance. Researchers leverage its cyclopropane scaffold to explore novel reaction pathways in organic synthesis.

Safety and Hazards

GHS Hazard Statements

• H301 (79.6%): Toxic if swallowed [Danger Acute toxicity, oral]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P270, P280, P301+P316, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (79.6%)
• Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.