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Atomfair 1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole C10H17BN2O2 CAS 847818-74-0

1-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS No. 847818-74-0) is a high-purity boronic ester derivative widely used in organic synthesis, pharmaceutical research, and materials science. This compound features a stable pinacol boronate group, making it an essential reagent for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry. With a molecular formula of C10H17BN2O2, it offers excellent solubility in common organic solvents such as THF, DMF, and dichloromethane, ensuring compatibility with diverse reaction conditions. Our product is rigorously tested for purity (≥97% by HPLC) and is supplied in sealed packaging under inert gas to ensure stability and longevity. Ideal for researchers and industrial chemists…

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Description

1-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS No. 847818-74-0) is a high-purity boronic ester derivative widely used in organic synthesis, pharmaceutical research, and materials science. This compound features a stable pinacol boronate group, making it an essential reagent for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry. With a molecular formula of C10H17BN2O2, it offers excellent solubility in common organic solvents such as THF, DMF, and dichloromethane, ensuring compatibility with diverse reaction conditions. Our product is rigorously tested for purity (≥97% by HPLC) and is supplied in sealed packaging under inert gas to ensure stability and longevity. Ideal for researchers and industrial chemists seeking reliable boron-containing intermediates for drug discovery and advanced material development.

Properties

  • CAS Number: 847818-74-0
  • Complexity: 242
  • IUPAC Name: 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
  • InChI: InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-7-12-13(8)5/h6-7H,1-5H3
  • InChI Key: HLXOVAMYQUFLPE-UHFFFAOYSA-N
  • Exact Mass: 208.1383080
  • Molecular Formula: C10H17BN2O2
  • Molecular Weight: 208.07
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC=NN2C
  • Topological: 36.3
  • Monoisotopic Mass: 208.1383080
  • Synonyms: 1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 628-091-8, 847818-74-0, 1-Methyl-1H-pyrazole-5-boronic acid pinacol ester, 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole, 1H-PYRAZOLE, 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-, MFCD05861380, 1-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole, 1-METHYLPYRAZOLE-5-BORONIC ACID PINACOL ESTER, 1H-PYRAZOLE,1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-, 4,4,5,5-tetramethyl-2-(1-methylpyrazol-5-yl)-1,3,2-dioxaborolane, 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL, 1-methyl-pyrazole-5-boronic acid pinacol ester, SCHEMBL332693, CHEMBL3236900, 1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole, DTXSID80406728, HLXOVAMYQUFLPE-UHFFFAOYSA-N, ALBB-012241, BCP14540, CS-M2919, SBB013484, TD8153, AKOS000302127, HN-0017, PB29351, NCGC00662690-01, AC-25463, SY017147, M2681, ST50570735, EN300-152536, 1-methyl-1-H-pyrazole-5-boronic acid pinacol ester, 1-Methyl-1H-pyrazole-5-boronic acid pinacol ester, 97%, F0001-3332, Z1336745146, (1-METHYL-1H-PYRAZOL-5-YL)BORONIC ACID PINACOL ESTER, 1-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROL, 1-methyl-5-(4,4,5,5-tetrarnethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 1-methyl-1H-pyrazol-5-ylboronate, 2-(1-METHYL-1H-PYRAZOL-5-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE, 2-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2H-PYRAZOLE

This boronic ester is primarily employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura) to construct biaryl and heteroaryl scaffolds prevalent in pharmaceuticals and agrochemicals. It serves as a key intermediate in the synthesis of kinase inhibitors and other bioactive molecules. The pinacol-protected boronate group enhances stability while maintaining reactivity under mild conditions. Suitable for automated synthesis platforms due to its consistent performance.

Safety and Hazards

GHS Hazard Statements

  • H302 (97.7%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (97.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (97.7%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)
  • STOT SE 3 (97.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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