Description

1-Isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS No. 879487-10-2) is a high-purity boronic ester derivative, widely utilized in Suzuki-Miyaura cross-coupling reactions and other palladium-catalyzed transformations. With the molecular formula C₁₂H₂₁BN₂O₂, this compound features a stable pinacol boronate group, ensuring excellent reactivity and shelf-life stability. Its isopropyl-substituted pyrazole core enhances steric control in coupling reactions, making it a valuable intermediate in pharmaceutical, agrochemical, and materials science research. This product is rigorously tested for purity (typically ≥95% by HPLC or NMR) and is available in sealed packaging under inert conditions to prevent degradation. Ideal for researchers seeking reliable boronic acid precursors in complex organic synthesis.

Properties

• CAS Number: 879487-10-2
• Complexity: 278
• IUPAC Name: 1-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
• InChI: InChI=1S/C12H21BN2O2/c1-9(2)15-8-10(7-14-15)13-16-11(3,4)12(5,6)17-13/h7-9H,1-6H3
• InChI Key: OGYYMVGDKVJYSU-UHFFFAOYSA-N
• Exact Mass: 236.1696081
• Molecular Formula: C12H21BN2O2
• Molecular Weight: 236.12
• SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CN(N=C2)C(C)C
• Topological: 36.3
• Monoisotopic Mass: 236.1696081
• Synonyms: 879487-10-2, 1-Isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 1-Isopropyl-1H-pyrazole-4-boronic acid pinacol ester, 1-isopropylpyrazole-4-boronic acid pinacol ester, 1-(1-Methylethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 1-propan-2-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole, 1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, MFCD11867881, 1-(propan-2-yl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 1-Isopropyl-1H-pyrazol-4-boronic acid, pinacol ester, (1-ISOPROPYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER, 1-ISOPROPYLPYRAZOLE-4-BORONIC ACID, PINACOL ESTER, 1-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole, 1-(propan-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 1-Isopropyl-1H-pyrazole-4-boronic acid pinacolester, 4,4,5,5-tetramethyl-2-[1-(methylethyl)pyrazol-4-yl]-1,3,2-dioxaborolane, 1-Isopropyl-1h-pyrazole-4-boronic acid, pinacol ester, SCHEMBL875957, 65K2Z25CVA, DTXSID50674174, OGYYMVGDKVJYSU-UHFFFAOYSA-N, SBB073727, STL415056, AKOS015922610, CS-W008377, SB11546, NCGC00662678-01, AS-19153, SY044810, DB-077148, I1085, ST51061770, EN300-212674, 1-Isopropyl-1H-pyrazole-4-boronic acid,pinacol ester, Z1741970851, 1-Isopropyl-1H-pyrazole-4-boronic acid pinacol ester, 97%, 1-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)1H-pyrazole, 1-isopropyl-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Application

This compound is primarily employed as a key intermediate in Suzuki-Miyaura cross-coupling reactions to construct biaryl or heteroaryl structures prevalent in drug discovery. Its pinacol boronate group offers improved handling compared to boronic acids, with applications in synthesizing kinase inhibitors and other bioactive molecules. The isopropyl-pyrazole moiety further enables targeted modifications in medicinal chemistry workflows.

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