Description

1-Fluorocyclopropane-1-carboxylic acid (CAS No. 137081-41-5) is a high-purity fluorinated cyclopropane derivative with the molecular formula C₄H₅FO₂. This specialized carboxylic acid features a fluorine atom at the 1-position of the cyclopropane ring, offering unique reactivity and steric properties for advanced synthetic applications. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied as a white to off-white crystalline solid with excellent batch-to-batch consistency. Ideal for pharmaceutical intermediates, agrochemical research, and materials science, this compound is packaged under inert gas in amber glass vials to ensure stability. Technical specifications include: molecular weight 104.08 g/mol, melting point 85-89°C, and storage recommendations of 2-8°C in a dry environment. MSDS and analytical certificates are available upon request.

Properties

• CAS Number: 137081-41-5
• Complexity: 106
• IUPAC Name: 1-fluorocyclopropanecarboxylic acid
• InChI: InChI=1S/C4H5FO2/c5-4(1-2-4)3(6)7/h1-2H2,(H,6,7)
• InChI Key: NDCPERCVXDYEFU-UHFFFAOYSA-N
• Exact Mass: 104.02735756
• Molecular Formula: C4H5FO2
• Molecular Weight: 104.08
• SMILES: C1CC1(C(=O)O)F
• Topological: 37.3
• Monoisotopic Mass: 104.02735756
• Synonyms: 1-fluorocyclopropane-1-carboxylic Acid, 821-923-2, 1-Fluorocyclopropanecarboxylic acid, 137081-41-5, 1-fluoro-cyclopropanecarboxylic acid, Cyclopropanecarboxylic acid, 1-fluoro-, MFCD18205954, C4H5FO2, SCHEMBL22866, SCHEMBL22867, 1-Fluorocyclopropanecarboxylicacid, DTXSID00430702, NDCPERCVXDYEFU-UHFFFAOYSA-N, 1-Fluoro-cyclopropanecarboxylicacid, BCP34593, 1-fluoro-cyclopropane-carboxylic acid, BBL102489, CS1878, GEO-04270, STL556292, AKOS006240288, CS-W001256, DS-4526, SB33102, AC-31160, FF104360, SY058672, F1254, EN300-55348, 1-Fluoro-cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-fluoro-

Application

1-Fluorocyclopropane-1-carboxylic acid serves as a versatile building block in medicinal chemistry, particularly for the synthesis of fluorinated analogs of bioactive compounds. The strained cyclopropane ring enhances binding affinity in drug discovery, while the fluorine atom improves metabolic stability. Researchers utilize this compound in peptide modifications and as a precursor for fluorinated heterocycles. Its unique structure also finds applications in material science for creating fluorinated polymers with tailored properties.

Safety and Hazards

GHS Hazard Statements

• H290 (33.3%): May be corrosive to metals [Warning Corrosive to Metals]
• H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (33.3%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (66.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (33.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P234, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P390, P403+P233, P405, P406, and P501

Hazard Classes and Categories

• Met. Corr. 1 (33.3%)
• Acute Tox. 4 (66.7%)
• Skin Corr. 1B (33.3%)
• Skin Irrit. 2 (66.7%)
• Eye Dam. 1 (66.7%)
• Eye Irrit. 2A (33.3%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.