Description

1-Fluoro-4-nitrobenzene (CAS No. 350-46-9), also known as 4-fluoronitrobenzene or p-fluoronitrobenzene, is a high-purity aromatic compound with the molecular formula C₆H₄FNO₂. This yellow crystalline solid is widely utilized in organic synthesis, pharmaceutical research, and agrochemical development due to its reactive nitro and fluoro substituents. With a molecular weight of 141.10 g/mol, it exhibits excellent solubility in organic solvents such as ethanol, ether, and benzene. Our product is rigorously tested to ensure ≥98% purity (GC), making it ideal for nucleophilic substitution reactions, cross-coupling protocols, and as a precursor for dyes and advanced materials. Proper storage in a cool, dry place is recommended to maintain stability.

Properties

• CAS Number: 350-46-9
• Complexity: 126
• IUPAC Name: 1-fluoro-4-nitro-benzene
• InChI: InChI=1S/C6H4FNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H
• InChI Key: WFQDTOYDVUWQMS-UHFFFAOYSA-N
• Exact Mass: 141.02260653
• Molecular Formula: C6H4FNO2
• Molecular Weight: 141.10
• SMILES: C1=CC(=CC=C1[N+](=O)[O-])F
• Topological: 45.8
• Monoisotopic Mass: 141.02260653
• Physical Description: Yellow solid; Liquid or low melting solid; mp = 22-24 deg C;
• Color/Form: YELLOW NEEDLES
• Boiling Point: 206-207 °C
• Melting Point: 27 °C
• Solubility: SOL IN ALCOHOL, ETHER; INSOL IN WATER
• Density: 1.3300 @ 20 °C/4 °C
• Vapor Pressure: 0.29 [mmHg]
• Refractive Index: MAX ABSORPTION : 212 NM ; 263 NM ; INDEX OF REFRACTION: 1.5316 @ 20 °C/D
• Synonyms: 4-Fluoronitrobenzene, 1-FLUORO-4-NITROBENZENE, 350-46-9, p-Fluoronitrobenzene, p-Nitrofluorobenzene, 4-Nitrofluorobenzene, Benzene, 1-fluoro-4-nitro-, 4-Fluoro-1-nitrobenzene, 1-Nitro-4-fluorobenzene, para-fluoronitrobenzene, NSC 10281, 4-nitro-1-fluorobenzene, HSDB 2735, A2M2FH7XHH, 4fluoronitrobenzene, EINECS 206-502-8, NSC-10281, 4-NITROPHENYL FLUORIDE, DTXSID9022025, EC 206-502-8, 1-NITRO-4-FLUOROBENZENE [HSDB], pFluoronitrobenzene, pNitrofluorobenzene, 4nitrofluorobenzene, 1Nitro4fluorobenzene, 4Fluoro1nitrobenzene, Benzene, 1fluoro4nitro, DTXCID802025, 206-502-8, inchi=1/c6h4fno2/c7-5-1-3-6(4-2-5)8(9)10/h1-4, 178603-76-4, 1-Fluoro-4-nitro-benzene, 1,4-Fluoronitrobenzene, Benzene, 1-fluoro-4-nitro-, labeled with carbon-14 (9CI), UNII-A2M2FH7XHH, 4-fluornitrobenzene, 4-fluronitrobenzene, 4-flouronitrobenzene, parafluoronitrobenzene, 4-nitrophenylfluoride, p-fluoro nitrobenzene, p-fluoro-nitrobenzene, p-fluoronitro benzene, 4-Fluro-nitrobenzene, 4-Fluoro-nitrobenzene, 4-fluoronitro benzene, 4-fluoronitro-benzene, 4-nitro-fluorobenzene, fluoro-4-nitrobenzene, p-fluoro -nitrobenzene, 1-fluoro4-nitrobenzene, 4-(fluoro)nitrobenzene, 4-fluoro nitro benzene, 4-fluoro-nitro-benzene, 4-fluoro1-nitrobenzene, 4-fluoro-l-nitrobenzene, 4-fluro-1-nitrobenzene, l-fluoro-4-nitrobenzene, 1-fiuoro-4-nitrobenzene, 1-fluoro-4nitro-benzene, Nitrobenzene, 4-fluoro-, WLN: WNR DF, SCHEMBL536, 1 -fluoro-4-nitrobenzene, 1-fluoro-4-nitro benzene, 4-fluoro-1-nitro-benzene, SCHEMBL146709, PARA FLUORO NITROBENZENE, CHEMBL163729, SCHEMBL2684523, SCHEMBL16591626, 1-Fluoro-4-nitrobenzene, 99%, NSC10281, BBL027638, MFCD08705010, MFCD28053761, SBB054149, STK399779, AKOS005207030, AKOS025395644, CS-W008789, PB47744, AS-11956, SY258665, SY322633, DB-003484, DB-103230, F0105, NS00004090, ST50586052, EN300-19364, 1-Fluoro-4-nitrobenzene, purum, >=98.0% (GC), Q27273534, F0001-1015, Z104473634, 4-Nitrofluorobenzene ; p-Fluoronitrobenzene;4-Fluoronitrobenzene

Application

1-Fluoro-4-nitrobenzene serves as a key intermediate in the synthesis of pharmaceuticals, including fluorinated anilines and heterocyclic compounds. It is employed in Suzuki-Miyaura cross-coupling reactions to create biaryl structures for material science applications. The compound’s electron-withdrawing properties make it valuable for studying reaction mechanisms in organic chemistry. Additionally, it is used to develop agrochemicals and dyes due to its ability to introduce fluorine into target molecules.

Safety and Hazards

GHS Hazard Statements

• H302 (88.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H317 (37.3%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (10.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (53.9%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H373 (52.9%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (88.2%)
• Acute Tox. 4 (50%)
• Skin Sens. 1 (37.3%)
• Eye Irrit. 2 (10.8%)
• Acute Tox. 3 (53.9%)
• STOT RE 2 (52.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.