Description

1-Fluoro-4-methoxy-2-nitrobenzene (CAS No. 61324-93-4) is a high-purity aromatic compound with the molecular formula C₇H₆FNO₃. This fine chemical is widely utilized in organic synthesis, pharmaceutical research, and material science due to its unique fluorinated nitroaromatic structure. Its distinct reactivity makes it an essential intermediate for constructing complex molecules, particularly in medicinal chemistry and agrochemical applications. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC), with detailed analytical data (NMR, MS) available upon request. Supplied in amber glass bottles under inert gas to ensure stability, it is ideal for researchers requiring precise and reliable building blocks for heterocyclic synthesis, cross-coupling reactions, or electrophilic substitution studies.

Properties

• CAS Number: 61324-93-4
• Complexity: 171
• IUPAC Name: 1-fluoro-4-methoxy-2-nitro-benzene
• InChI: InChI=1S/C7H6FNO3/c1-12-5-2-3-6(8)7(4-5)9(10)11/h2-4H,1H3
• InChI Key: ZRIKJXDEJYMBEJ-UHFFFAOYSA-N
• Exact Mass: 171.03317122
• Molecular Formula: C7H6FNO3
• Molecular Weight: 171.13
• SMILES: COC1=CC(=C(C=C1)F)[N+](=O)[O-]
• Topological: 55.1
• Monoisotopic Mass: 171.03317122
• Synonyms: 1-Fluoro-4-methoxy-2-nitrobenzene, 821-328-8, 4-Fluoro-3-nitroanisole, 61324-93-4, 1-Fluoro-4-methoxy-2-nitro-Benzene, Benzene, 1-fluoro-4-methoxy-2-nitro-, MFCD11848442, 3-Fluoro-4-nitrobenzene,-1-methoxy, 2-fluoro-5-methoxynitrobenzene, SCHEMBL3192746, 2-Fluoro-5-methoxy-nitrobenzene, DTXSID00340559, BBL102165, STL555964, TD1020, 1-Fluoro-4-methoxy-2-nitrobenzene #, AKOS015854343, CS-W007748, FF67718, GS-4321, AC-28592, SY027279, EN300-177174

1-Fluoro-4-methoxy-2-nitrobenzene serves as a versatile precursor in the synthesis of pharmaceuticals, particularly for introducing fluorine-containing motifs into drug candidates. It is employed in nucleophilic aromatic substitution (SNAr) reactions to create aniline derivatives or heterocycles. Researchers also utilize it in palladium-catalyzed cross-couplings for constructing biaryl systems. Its electron-withdrawing nitro group enhances reactivity in reduction and cyclization workflows.

Safety and Hazards

GHS Hazard Statements

• H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (25%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H412 (25%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (75%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (75%)
• Eye Irrit. 2 (75%)
• Acute Tox. 4 (25%)
• STOT SE 3 (50%)
• Aquatic Chronic 3 (25%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.