Description

1-Fluoro-2-nitrobenzene (CAS No. 1493-27-2) is a high-purity aromatic compound with the molecular formula C₆H₄FNO₂, widely used in organic synthesis and pharmaceutical research. This yellow crystalline solid exhibits excellent reactivity as an intermediate in nucleophilic substitution reactions, owing to the electron-withdrawing effects of both the fluorine and nitro groups. With a molecular weight of 141.10 g/mol, it is soluble in organic solvents such as ethanol, ether, and acetone but insoluble in water. Ideal for researchers and industrial chemists, our product is rigorously tested for purity (typically ≥98% by GC) and consistency, ensuring reliable performance in synthetic applications. Proper storage in a cool, dry place under inert conditions is recommended to maintain stability.

Properties

• CAS Number: 1493-27-2
• Complexity: 134
• IUPAC Name: 1-fluoro-2-nitro-benzene
• InChI: InChI=1S/C6H4FNO2/c7-5-3-1-2-4-6(5)8(9)10/h1-4H
• InChI Key: PWKNBLFSJAVFAB-UHFFFAOYSA-N
• Exact Mass: 141.02260653
• Molecular Formula: C6H4FNO2
• Molecular Weight: 141.10
• SMILES: C1=CC=C(C(=C1)[N+](=O)[O-])F
• Topological: 45.8
• Monoisotopic Mass: 141.02260653
• Physical Description: Clear yellow liquid;
• Vapor Pressure: 0.29 [mmHg]
• Synonyms: 1-Fluoro-2-nitrobenzene, 1493-27-2, 2-Fluoronitrobenzene, o-Fluoronitrobenzene, Benzene, 1-fluoro-2-nitro-, o-Nitrofluorobenzene, 2-Nitrofluorobenzene, Benzene, o-nitrofluoro-, EINECS 216-088-0, NSC 51869, DTXSID1061730, EC 216-088-0, oNitrofluorobenzene, 2Nitrofluorobenzene, Benzene, onitrofluoro, Benzene, 1fluoro2nitro, DTXCID2034837, 216-088-0, inchi=1/c6h4fno2/c7-5-3-1-2-4-6(5)8(9)10/h1-4, 127723-77-7, 2-fluoro-1-nitrobenzene, 1-Fluoro-2-nitro-benzene, MFCD00007048, Fluoronitrobenzene, NSC-51869, Benzene, 1-fluoro-2-nitro-, labeled with carbon-14 (9CI), Benzene, fluoronitro-, nitrofluorobenzene, ORTHO FLUORO NITROBENZENE, 2fluoronitrobenzene, o-fluronitrobenzene, 2-fluoronitrobenzen, 1-fluoronitrobenzene, o-fluoro-nitrobenzene, o-fluoronitro-benzene, 1-Fluoro-nitrobenzene, 2-fluoro nitrobenzene, 2-Fluoro-nitrobenzene, 2-nitro fluorobenzene, 2-nitro-fluorobenzene, ortho-fluoronitrobenzene, 1-fluor-2-nitrobenzol, 2-fluoro-nitro-benzene, 1-fluor-2-nitrobenzene, l-fluoro-2-nitrobenzene, 2-nitro-1-fluorobenzene, 1-Flouro-2-nitrobenzene, 9WUK5DS6YX, 1-fluoro-2-nitro benzene, 2-fluoro-1-nitro-benzene, SCHEMBL5828, CHEMBL49252, SCHEMBL407090, SCHEMBL710076, SCHEMBL2075134, SCHEMBL2075135, SCHEMBL16474073, 1-Fluoro-2-nitrobenzene, 99%, NSC51869, SBB063156, STL183282, AKOS000120023, CS-W008586, FF37242, AS-11953, BP-20685, DB-019183, DB-347060, F0104, NS00001700, ST51038588, EN300-20388, Q63398793, F0001-0531, Z104477992, O-Fluoronitrobenzene;2-Fluoronitrobenzene;1-Fluoro-2-nitrobenzene

Application

1-Fluoro-2-nitrobenzene serves as a versatile building block in the synthesis of agrochemicals, pharmaceuticals, and dyes. Its electron-deficient aromatic ring facilitates nucleophilic aromatic substitution (SNAr) reactions, making it valuable for creating fluorinated anilines and heterocycles. Researchers also employ it in the development of liquid crystals and advanced materials. Additionally, it is used as a precursor in palladium-catalyzed cross-coupling reactions for constructing complex organic frameworks.

Safety and Hazards

GHS Hazard Statements

• H301 (79.1%): Toxic if swallowed [Danger Acute toxicity, oral]
• H310 (19.4%): Fatal in contact with skin [Danger Acute toxicity, dermal]
• H311 (60.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (43.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (43.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (20.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (23%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (79.1%)
• Acute Tox. 2 (19.4%)
• Acute Tox. 3 (60.2%)
• Skin Irrit. 2 (43.5%)
• Eye Irrit. 2 (43.5%)
• STOT SE 3 (20.9%)
• STOT RE 2 (23%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.