Description

1-Fluoro-2-iodobenzene (CAS: 348-52-7) is a high-purity halogenated aromatic compound with the molecular formula C₆H₄FI. This specialty chemical is widely used in organic synthesis, pharmaceutical research, and material science due to its reactive fluoro and iodo substituents, which enable versatile functionalization. Available in stabilized form (0.01% copper chip), it ensures prolonged shelf life and consistent performance. Ideal for Suzuki couplings, nucleophilic substitutions, and cross-coupling reactions, this reagent is rigorously tested for purity (≥98%) and supplied with detailed analytical documentation (GC/MS, NMR). Packaged under inert gas to prevent degradation, it meets the stringent requirements of industrial and academic laboratories.

Properties

• CAS Number: 348-52-7
• Complexity: 74.9
• IUPAC Name: 1-fluoro-2-iodo-benzene
• InChI: InChI=1S/C6H4FI/c7-5-3-1-2-4-6(5)8/h1-4H
• InChI Key: TYHUGKGZNOULKD-UHFFFAOYSA-N
• Exact Mass: 221.93418
• Molecular Formula: C6H4FI
• Molecular Weight: 222.00
• SMILES: C1=CC=C(C(=C1)F)I
• Monoisotopic Mass: 221.93418
• Synonyms: 1-Fluoro-2-iodobenzene, 348-52-7, o-Fluoroiodobenzene, Benzene, 1-fluoro-2-iodo-, EINECS 206-477-3, NSC 51766, DTXSID3059842, DTXCID6038904, inchi=1/c6h4fi/c7-5-3-1-2-4-6(5)8/h1-4, tyhugkgznoulkd-uhfffaoysa-n, 2-Fluoroiodobenzene, o-Iodofluorobenzene, 2-iodofluorobenzene, 1-fluoro-2-iodo-benzene, 2-fluoro-iodobenzene, 2-Fluoroiodobenzene,contains copper as stabilizer, 1-iodo-2-fluorobenzene, 2-fluoro-1-iodobenzene, 2-fluroiodobezene, NSC51766, 2-fluoro iodobenzene, MFCD00001031, 1-Fluor-2-jod-benzol, SCHEMBL12683, SCHEMBL1798111, SCHEMBL1798114, SCHEMBL4032027, SCHEMBL4035082, SCHEMBL9405745, CS-D1738, NSC-51766, SBB096229, AKOS005258232, FF105628, HY-34673, DB-002375, 98% (stabilized with 0.01% Copper chip), F0253, NS00041664, D77356, EN300-111650, 2-Fluoroiodobenzene, 99%, contains copper as stabilizer, F0001-1008, Z381540762

1-Fluoro-2-iodobenzene serves as a key intermediate in pharmaceutical synthesis, particularly for fluorinated drug candidates. Its reactivity in palladium-catalyzed cross-coupling reactions (e.g., Heck, Sonogashira) makes it valuable for constructing complex aromatic scaffolds. Researchers also utilize it in agrochemical development and OLED material design. Stabilized with copper, it ensures reliable performance in high-temperature reactions.

Safety and Hazards

GHS Hazard Statements

• H302 (86%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (98%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (80%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (18%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (16%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (86%)
• Skin Irrit. 2 (98%)
• Eye Dam. 1 (80%)
• Eye Irrit. 2A (18%)
• STOT SE 3 (16%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.