Description

1-(Chloromethyl)-2,4-difluorobenzene (CAS No. 452-07-3) is a high-purity aromatic compound with the molecular formula C₇H₅ClF₂. This organofluorine building block features a reactive chloromethyl group and two fluorine substituents on the benzene ring, making it a versatile intermediate for pharmaceutical, agrochemical, and materials science applications. The compound is supplied as a clear, colorless to pale yellow liquid with a molecular weight of 162.56 g/mol and a density of approximately 1.29 g/cm³. It is moisture-sensitive and should be stored under inert atmosphere at 2-8°C. Our product is rigorously tested by HPLC, GC, and NMR to ensure >98% purity, with detailed certificates of analysis available upon request. Suitable for use in nucleophilic substitution reactions, cross-coupling chemistry, and as a precursor for bioactive molecules.

Properties

• CAS Number: 452-07-3
• Complexity: 108
• IUPAC Name: 1-(chloromethyl)-2,4-difluoro-benzene
• InChI: InChI=1S/C7H5ClF2/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2
• InChI Key: XPGHWBDZNQUUQD-UHFFFAOYSA-N
• Exact Mass: 162.0047842
• Molecular Formula: C7H5ClF2
• Molecular Weight: 162.56
• SMILES: C1=CC(=C(C=C1F)F)CCl
• Monoisotopic Mass: 162.0047842
• Synonyms: 1-(chloromethyl)-2,4-difluorobenzene, 672-587-7, 2,4-Difluorobenzyl chloride, 452-07-3, MFCD01090988, 2,4-difluorobenzylchloride, 1-(chloromethyl)-2,4-difluoro-benzene, Benzene, 1-(chloromethyl)-2,4-difluoro-, alpha-Chloro-2,4-difluorotoluene, 2,4-difluoro-benzyl chloride, SCHEMBL1503215, SCHEMBL28821844, DTXSID80371725, ALBB-006038, CK1010, SBB048038, STK503683, AKOS000262025, AC-9732, PS-10668, SY040263, D3493, EN300-61214

Application

1-(Chloromethyl)-2,4-difluorobenzene serves as a key synthetic intermediate in the preparation of fluorinated pharmaceuticals, particularly for CNS-active compounds and antifungal agents. The chloromethyl group enables facile functionalization through nucleophilic displacement reactions, while the difluoro substitution pattern influences both electronic properties and metabolic stability of resulting molecules. This compound is also employed in material science for modifying polymer properties and in agricultural chemistry for developing novel crop protection agents.

Safety and Hazards

GHS Hazard Statements

• H290 (14.3%): May be corrosive to metals [Warning Corrosive to Metals]
• H302 (14.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (28.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H332 (14.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P234, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P390, P405, P406, and P501

Hazard Classes and Categories

• Met. Corr. 1 (14.3%)
• Acute Tox. 4 (14.3%)
• Skin Corr. 1B (100%)
• Eye Dam. 1 (28.6%)
• Acute Tox. 4 (14.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.