Description

1-Chloro-3-fluorobenzene (CAS No. 625-98-9) is a high-purity halogenated aromatic compound with the molecular formula C₆H₄ClF. This colorless to pale-yellow liquid is widely used in organic synthesis, pharmaceutical intermediates, and agrochemical research due to its reactive chloro and fluoro substituents in the meta position. With a boiling point of approximately 124-126°C and a density of 1.19 g/cm³, it exhibits excellent solubility in common organic solvents like ethanol, ether, and dichloromethane. Our product is rigorously tested to ensure ≥99% purity (GC), making it ideal for sensitive applications in medicinal chemistry, material science, and cross-coupling reactions. Packaged under inert gas in amber glass bottles to prevent degradation, it is supplied with comprehensive analytical data (GC/MS, NMR) for quality assurance.

Properties

• CAS Number: 625-98-9
• Complexity: 74.9
• IUPAC Name: 1-chloro-3-fluoro-benzene
• InChI: InChI=1S/C6H4ClF/c7-5-2-1-3-6(8)4-5/h1-4H
• InChI Key: VZHJIJZEOCBKRA-UHFFFAOYSA-N
• Exact Mass: 129.9985560
• Molecular Formula: C6H4ClF
• Molecular Weight: 130.55
• SMILES: C1=CC(=CC(=C1)Cl)F
• Monoisotopic Mass: 129.9985560
• Physical Description: Colorless liquid;
• Vapor Pressure: 8.19 [mmHg]
• Synonyms: 1-Chloro-3-fluorobenzene, Benzene, 1-chloro-3-fluoro-, 1-Chloro-3-fluoro-benzene, DTXSID70870717, BENZENE,1-CHLORO,3-FLUORO, mChlorofluorobenzene, mFluorochlorobenzene, 3Chlorofluorobenzene, 1Fluoro3chlorobenzene, Benzene, 1chloro3fluoro, DTXCID30818413, 210-919-0, einecs 210-919-0, inchi=1/c6h4clf/c7-5-2-1-3-6(8)4-5/h1-4, nsc 10271, un1993, vzhjijzeocbkra-uhfffaoysa-n, 625-98-9, 3-Chlorofluorobenzene, m-Chlorofluorobenzene, 3-Fluorochlorobenzene, m-Fluorochlorobenzene, 1-Fluoro-3-chlorobenzene, MFCD00000569, NSC10271, m-fluoro chlorobenzene, 3-fluoro-chlorobenzene, 3-fluoro-1-chlorobenzene, SCHEMBL26988, SCHEMBL134875, SCHEMBL147682, SCHEMBL159601, SCHEMBL165706, SCHEMBL502616, SCHEMBL6201152, SCHEMBL7933207, 1-Chloro-3-fluorobenzene, 99%, NSC-10271, SBB085773, AKOS000120022, PS-11968, NS00042923, EN300-21385, F8880-8320

1-Chloro-3-fluorobenzene serves as a versatile building block in Suzuki-Miyaura and Ullmann coupling reactions for synthesizing biaryl structures. It is employed in the development of liquid crystal materials and pharmaceutical intermediates, particularly for fluorinated active ingredients. The compound also finds use as a precursor in the manufacture of agrochemicals and specialty polymers requiring meta-substituted aromatic frameworks.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H315 (92%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (92%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (16%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (88%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Skin Irrit. 2 (92%)
• Eye Irrit. 2 (92%)
• Acute Tox. 4 (16%)
• STOT SE 3 (88%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.