Description

1-Chloro-2-fluorobenzene (CAS No. 348-51-6) is a high-purity halogenated aromatic compound with the molecular formula C₆H₄ClF. This colorless to pale-yellow liquid is a versatile intermediate in organic synthesis, particularly in pharmaceutical, agrochemical, and material science applications. With a boiling point of 139-140°C and a density of 1.24 g/cm³, it exhibits excellent stability under standard conditions. Packaged in amber glass bottles or sealed drums under inert gas to ensure longevity, our product undergoes rigorous QC testing (GC purity ≥98%) to meet the demands of research and industrial processes. Synonyms include o-Chlorofluorobenzene and NSC 10270.

Properties

• CAS Number: 348-51-6
• Complexity: 74.9
• IUPAC Name: 1-chloro-2-fluoro-benzene
• InChI: InChI=1S/C6H4ClF/c7-5-3-1-2-4-6(5)8/h1-4H
• InChI Key: ZCJAYDKWZAWMPR-UHFFFAOYSA-N
• Exact Mass: 129.9985560
• Molecular Formula: C6H4ClF
• Molecular Weight: 130.55
• SMILES: C1=CC=C(C(=C1)F)Cl
• Monoisotopic Mass: 129.9985560
• Physical Description: Colorless liquid;
• Vapor Pressure: 8.19 [mmHg]
• Synonyms: 1-CHLORO-2-FLUOROBENZENE, o-Chlorofluorobenzene, Benzene, 1-chloro-2-fluoro-, NSC 10270, EINECS 206-476-8, DTXSID8059841, oChlorofluorobenzene, oFluorochlorobenzene, 1Fluoro2chlorobenzene, Benzene, 1chloro2fluoro, DTXCID1038903, 206-476-8, inchi=1/c6h4clf/c7-5-3-1-2-4-6(5)8/h1-4, un1993, zcjaydkwzawmpr-uhfffaoysa-n, 348-51-6, 2-Chlorofluorobenzene, o-Fluorochlorobenzene, 1-Fluoro-2-chlorobenzene, 1-chloro-2-fluoro-benzene, CHLOROFLUOROBENZENE, NSC-10270, Benzene, chlorofluoro-, 2-FLUOROCHLOROBENZENE, ortho-chlorofluorobenzene, JUQ2V3V2AA, SCHEMBL19921, SCHEMBL68590, SCHEMBL68591, SCHEMBL118251, SCHEMBL168042, SCHEMBL1001352, 1-Chloro-2-fluorobenzene, 98%, 1-Chloro-2-fluorobenzene, 99%, NSC10270, MFCD00000533, SBB085774, AKOS005063959, DS-1906, A6119, NS00042080, EN300-20293, A20498, M-Chlorofluorobenzene;1-chloro-3-fluoro-benzen

Application

1-Chloro-2-fluorobenzene serves as a key building block in Suzuki coupling reactions for pharmaceutical synthesis. It is widely used to introduce fluorine-substituted phenyl groups into active pharmaceutical ingredients (APIs) and liquid crystal materials. The compound also acts as a precursor for herbicides and pesticides due to its selective reactivity.

Safety and Hazards

GHS Hazard Statements

• H226 (94.2%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (92.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (92.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (15.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (11.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (94.2%)
• Skin Irrit. 2 (92.3%)
• Eye Irrit. 2A (92.3%)
• Acute Tox. 4 (15.4%)
• STOT SE 3 (11.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.