Description

Description

1-Cbz-pyrrolidine (Benzyl pyrrolidine-1-carboxylate) is a high-purity organic compound with the molecular formula C₁₂H₁₅NO₂ and CAS number 25070-74-0. This versatile carbamate-protected pyrrolidine derivative is widely used in pharmaceutical research, peptide synthesis, and medicinal chemistry applications. The product is supplied as a clear to pale yellow liquid or low-melting solid, offering excellent solubility in common organic solvents such as dichloromethane, ethyl acetate, and dimethylformamide.

With a molecular weight of 205.25 g/mol, this compound serves as a valuable building block for the introduction of the pyrrolidine moiety in complex molecular architectures. The Cbz (carboxybenzyl) protecting group can be selectively removed under mild hydrogenation conditions, making it particularly useful for multi-step synthetic routes. Our product undergoes rigorous quality control to ensure ??95% purity by HPLC, with comprehensive characterization including ¹H NMR, ¹³C NMR, and mass spectral data available upon request.

Proper storage at 2-8??C under inert atmosphere ensures long-term stability. Suitable for research and development purposes only, not for drug, household, or other uses.

Application

1-Cbz-pyrrolidine is primarily employed as a protected intermediate in the synthesis of pyrrolidine-containing pharmaceuticals and bioactive compounds. The Cbz group provides excellent protection for the pyrrolidine nitrogen during multi-step synthetic sequences, particularly in peptide chemistry and heterocyclic drug development. This reagent finds specific utility in the preparation of protease inhibitors, neurotransmitter analogs, and various CNS-active compounds. The protecting group can be selectively removed via hydrogenolysis or acidolysis, allowing for subsequent functionalization of the pyrrolidine scaffold.

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